Detection and analysis of plasma D-dimer in healthy pregnant women

doi:10.3969/j.issn.1673-8640.2014.10.002

Abstract

Abstract:

Objective To investigate the change characteristics of plasma D-dimer in healthy pregnant women and establish the reference range. Methods A total of 664 healthy pregnant women and 100 healthy women without pregnancy as control group were enrolled, and there were 18 cases of disseminated intravascular coagulation (DIC) or venous thrombosis after delivery. They were classified into 5 groups, pregnancy <20 weeks (127 cases), pregnancy 20-32 weeks (86 cases), pregnancy ≥32 weeks (191 cases), the first postpartum day (130 cases) and the second postpartum day (130 cases). D-dimer concentration was determined by SYSMEX CA7000 automatic coagulation analyzer in order to identify the reference range. Since D-dimer concentration showed non-normal distribution, the normal values were established by percentile (P95). The results of the 18 cases of DIC or venous thrombosis were used to validate the established normal values. Resutls D-dimer concentration increased continually with pregnancy from 20 weeks to 32 weeks, especially after 32 weeks. The reference ranges were <1.54 mg/L, <3.46 mg/L and <4.96 mg/L for pregnancy <20 weeks, 20-32 weeks and ≥32 weeks. D-dimer had a significant change during childbirth, and there was a sharp increasing in the first postpartum day and a significant decline in the second postpartum day recovering to the levels of late pregnancy, which the reference ranges were <11.76 mg/L and <5.87 mg/L, respectively.All groups had statistical significance for D-dimer concentration (P<0.001). The percentages of D-dimer which were lower than conventional critical value to exclude DVT (0.5 mg/L)were 92.3%, 55.1%, 7.0%, 1.0%, 0.2% and 0.7% in control group and 5 groups in pregnancy, respectively. All the 18 cases of DIC or venous thrombosis showed positive results by the above normal values. Conclusions By analyzing the change characteristics of D-dimer in healthy pregnant women, D-dimer reference ranges in healthy pregnant women are established. The D-dimer in middle and late pregnancy is not specific, which can not be as exclusion parameter.

Key words: D-dimer, Pregnant woman, Reference range

CLC Number:

R446.11

WU Li, ZHOU Cai, HUANG Ruiyu, LIU YAN.. Detection and analysis of plasma D-dimer in healthy pregnant women[J]. , 2014, 29(10): 992-994.

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