Abstract:

Objective To investigate the diagnostic roles of neutrophil/lymphocyte ratio（NLR）,C-reactive protein（CRP）,procalcitonin（PCT）,D-dimer（DD） and amino terminal B-type natriuretic peptide（NT-proBNP）in severe corona virus disease 2019（COVID-19）. Methods A total of 105 COVID-19 patients were enrolled. According to COVID-19 diagnostic criteria,these patients were classified into general group（83 cases）and severe group（22 cases）. Fifty healthy subjects were enrolled as control group. The age,sex,white blood cell（WBC）count,the absolute value of neutrophil（NEUT#）,the absolute value of lymphocyte（LYMPH#）,NLR,CRP,PCT,DD and NT-proBNP of the 3 groups were compared. Results The patients in general and severe groups were older than healthy subjectsand were predominantly male. The patients in severe group were significantly older than those in general group（P<0.05）. Compared with general group,WBC count,NEUT#,NLR,CRP,PCT,DD and NT-proBNP were higher in severe group,and LYMPH# was lower（P<0.05）. General group had higher levels of NLR,CRP,DD and NT-proBNP than healthy control group,while WBC count and LYMPH# were on the contrary（P<0.05）. NT-proBNP had the highest diagnostic value for severe COVID-19,and the combined determination had better performance than single determination. The sensitivity,specificity,positive predictive value and negative predictive value of NT-proBNP were 95.45%,93.98%,80.77% and 98.73%,respectively. Conclusion NT-proBNP is of high diagnostic value for severe COVID-19. The combined determination of NT-proBNP,NLR,CRP,PCT and DD has higher value in the diagnosis of severe COVID-19.

Key words: Neutrophil/lymphocyte ratio, C-reactive protein, Procalcitonin, Amino terminal B-type natriuretic peptide, D-dimer, Corona virus disease 2019