Abstract:

Objective To investigate the roles of serum soluble intercellular adhesion molecule-1（sICAM-1） and high-sensitivity C-reactive protein（hs-CRP） levels in monitoring acute viral lower respiratory tract infection in children. Methods Totally,136 children with acute viral lower respiratory tract infection were enrolled and classified into mild-moderate group（82 cases） and severe group（54 cases） according to severity. According to specific IgG antibody level,they were classified into acute phase and recovery phase groups. According to acute physiology and chronic health evaluation Ⅱ（APACHEⅡ）score,children were classified into low-risk group（39 cases）,intermediate-risk group（57 cases） and high-risk group（40 cases）. Serum sICAM-1,hs-CRP levels and oxygenation index were determined. Totally,50 healthy children were enrolled as healthy control group. Pearson correlation analysis was used to evaluate the correlation between various indicators. Results In acute phase,serum sICAM-1 and hs-CRP levels in severe group and mild-moderate group were higher than those in healthy control group（P<0.05）,and serum sICAM-1 and hs-CRP levels in severe group were higher than those in mild-moderate group（P<0.05）. The levels of serum sICAM-1 and hs-CRP in low-risk group,intermediate-risk group and high-risk group increased in turn（P<0.05）. The levels of serum sICAM-1 and hs-CRP in acute and recovery phases of severe group were higher than those of mild-moderate group（P<0.05）. The levels of serum sICAM-1 and hs-CRP in recovery phase were lower than those in acute phase（P<0.05）. The results of Pearson correlation analysis showed that serum sICAM-1 and hs-CRP levels in acute phase of children with acute viral lower respiratory tract infection were positively correlated with APACHE Ⅱ score（r values were 0.79 and 0.70,P<0.05）,and the indicators were negatively correlated to oxygenation index before treatment（r values were -0.54 and -0.46,P<0.05）. Conclusions The levels of serum sICAM-1 and hs-CRP in children with acute viral lower respiratory tract infection can reflect the development and severity of children's condition,and they can be used as reference indicators for monitoring children's condition.

Key words: Soluble intercellular adhesion molecule-1, High-sensitivity C-reactive protein, Oxygenation index, Acute viral lower respiratory tract infection, Children