Abstract:

Objective To investigate the epidemiological characteristics of Mycoplasma pneumoniae infection in children in Shanghai，and to provide a reference for the prevention and control of Mycoplasma pneumoniae infection. Methods The serological determination（passive agglutination），colloidal gold method and real-time quantitative polymerase chain reaction（PCR） results for Mycoplasma pneumoniae IgM and DNA for 18 718 patients with Mycoplasma pneumoniae infection from January 2014 to December 2018 were collected retrospectively and analyzed statistically. Factors，such as age，sex and season，were analyzed. Results The positive rate of serological determination（passive agglutination） in 18 718 cases was 30.48%. The positive rate of girls （34.91%） was higher than that of boys （27.22%）（P<0.01）. The results of screening Mycoplasma pneumoniae IgM by colloidal gold method and real-time quantitative PCR confirmed that the positive rate of girls was higher than that of boys （P<0.01）. The positive rate of infants （<1-year-old） was the lowest，the positive rate was increasing with ages，and the positive rate of 7-14-year-old group was the highest（P<0.01）. In terms of months，July to September of each year was the seasonal peak of Mycoplasma pneumoniae infection. Conclusions The positive rate of Mycoplasma pneumoniae antibodies in children with respiratory tract diseases in Shanghai is relatively high，and the positive rates between girls and boys and with different ages are different. July to September is the peak months of Mycoplasma pneumoniae infection.

Key words: Mycoplasma pneumoniae, Children, Serology, Epidemiology