Research progress in influenza viruses

doi:10.3969/j.issn.1673-8640.2023.07.015

Abstract

Abstract:

Influenza is a highly infectious acute respiratory disease caused by influenza virus infection. It has severe pathogenicity and high mortality. In the recent years，the study of influenza viruses has made certain progress，but in the development of drugs and vaccines for influenza viruses it is still inadequate，and the development trend of influenza virus variation situation at present can not be predicted，so this needs scientific research workers focusing on the etiology and pathogenic mechanism of influenza viruses. In this review，the etiology，epidemiology，pathogenic mechanism，influenza-associated pneumonia and acute respiratory distress syndrome were reviewed.

Key words: Influenza virus, Epidemiology, Host immune response, Cell apoptosis, Influenza-associated pneumonia, Acute respiratory distress syndrome

CLC Number:

R373.1

CHEN Danyang, ZHENG Siyu, ZHENG Ruilin, SU Jingyao, ZHU Bing, LI Yinghua. Research progress in influenza viruses[J]. Laboratory Medicine, 2023, 38(7): 696-703.

Figures/Tables 1

References 47

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RNA片段^①	编码的蛋白质	蛋白质功能
1	PB2	RNA聚合酶组分，参与病毒遗传物质的复制和转录
2	PB1	RNA聚合酶组分，参与病毒遗传物质的复制和转录
3	PA	RNA聚合酶组分，参与病毒遗传物质的复制和转录
4	HA	血凝素，介导病毒吸附和病毒包膜-内体膜融合
5	NP	核蛋白，参与构成核糖核蛋白，参与病毒RNA的合成
6	NA	神经氨酸酶，清除细胞表面的唾液酸，防止病毒颗粒聚集，促进病毒的释放
7	MP（包括M1、M2）	M1为基质蛋白，促进病毒装配，维持病毒的形态；M2为离子通道型跨膜蛋白，促进病毒脱壳
8	NS（包括NS1、NS2）	非结构蛋白；NS1可抑制mRNA前体的拼接和干扰素产生，NS2可促进病毒RNA的表达及转运。

RNA片段^①	编码的蛋白质	蛋白质功能
1	PB2	RNA聚合酶组分，参与病毒遗传物质的复制和转录
2	PB1	RNA聚合酶组分，参与病毒遗传物质的复制和转录
3	PA	RNA聚合酶组分，参与病毒遗传物质的复制和转录
4	HA	血凝素，介导病毒吸附和病毒包膜-内体膜融合
5	NP	核蛋白，参与构成核糖核蛋白，参与病毒RNA的合成
6	NA	神经氨酸酶，清除细胞表面的唾液酸，防止病毒颗粒聚集，促进病毒的释放
7	MP（包括M1、M2）	M1为基质蛋白，促进病毒装配，维持病毒的形态；M2为离子通道型跨膜蛋白，促进病毒脱壳
8	NS（包括NS1、NS2）	非结构蛋白；NS1可抑制mRNA前体的拼接和干扰素产生，NS2可促进病毒RNA的表达及转运。