Abstract:

Objective In order to provide the epidemiological data for clinical diagnosis, to analyze the distribution of urinary albumin (Alb) and estimated glomerular filtration rate (eGFR) in one-community elderly residents of Shanghai and the related risk factors. MethodsA total of 1 154 residents were randomly enrolled from Youyi Community, Baoshan District. All of them were ≥60 years old. Fasting blood and first morning urine samples were collected to measure and calculate urinary Alb/creatinine (Cr) ratio(ACR) and eGFR by the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI) equation. ACR≥30 mg/mgCr and eGFR≤60 mL/(min·1.73 m²) were used as the cut-off points to define albuminuria and impaired glomerular filtration rate (GFR). The prevalence and relationships between risk factors and disease were analyzed. The eGFR was calculated according to modification of diet in renal disease (MDRD) equation. Difference between the results of CKD-EPI equation and MDRD equation were also compared. ResultsOverall, 13.43% of the residents had albuminuria, and 29.98% of the residents existed impaired GFR. The abnormal rates of ACR and eGFR_CKD-EPI increased with sex, age, prevalence rate of diabetes mellitus, prevalence rate of hypertension showed statistical significance between normal group and albuminuria group (for sex: P<0.05; for the others: P<0.001). In impaired GFR group, all factors showed no statistical significances except age (P<0.001) and hypertension (P=0.006) compared with normal group (P>0.05). Compared with CKD-EPI equation, MDRD equation may get a higher abnormal rate of eGFR. MDRD equation may overestimate the abnormal rate and underestimate the eGFR levels of healthy subjects, especially in the elderly group and ACR normal group. CKD-EPI equation was relatively more accurate. ConclusionsThe prevalence of increasing ACR and abnormal eGFR is high among the elderly residents. Therefore, these individuals need to pay more attention to kidney disease, diabetes mellitus, hypertension and other risk factors. Clinicians should be aware of the differences of eGFR on the basis of different equations among different populations.

Key words: Urinary albumin/creatinine ratio, Estimated glomerular filtration rate, Epidemiology