doi:10.3969/j.issn.1673-8640.2023.07.016

Abstract

CLC Number:

R446.1

Figures/Tables 3

References 15

[1]	KRIVTSOV A V, HOSHII T, ARMSTRONG S A. Mixed-lineage leukemia fusions and chromatin in leukemia[J]. Cold Spring Harb Perspect Med, 2017, 7(11):a026658. DOI URL
[2]	MEYER C, BURMEISTER T, GRÖGER D, et al. The MLL recombinome of acute leukemias in 2017[J]. Leukemia, 2018, 32(2):273-284. DOI PMID
[3]	STREHL S, KÖNIG M, MEYER C, et al. Molecular dissection of t(11;17)in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants[J]. Genes Chromosomes Cancer, 2006, 45(11):1041-1049. DOI URL
[4]	弓晓媛, 王迎, 刘兵城, 等. MLL基因重排成人急性髓系白血病的特征和预后分析[J]. 中华血液学杂志, 2018, 39(1):9-14.
[5]	SUZUKAWA K, SHIMIZU S, NEMOTO N, et al. Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21)[J]. Int J Hematol, 2005, 82(1):38-41. PMID
[6]	DE BRAEKELEER E, MEYER C, DOUET-GUILBERT N, et al. Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory[J]. Mol Oncol, 2011, 5(6):555-563. DOI PMID
[7]	PRASAD R, LESHKOWITZ D, GU Y, et al. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1(MLL)in acute leukemia[J]. Proc Natl Acad Sci U S A, 1994, 91(17):8107-8111. DOI URL
[8]	CHAPLIN T, AYTON P, BERNARD O A, et al. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11)translocation in acute leukemia[J]. Blood, 1995, 85(6):1435-1441. DOI URL
[9]	LIN Y M, ONO K, SATOH S, et al. Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis[J]. Cancer Res, 2001, 61(17):6345-6349. PMID
[10]	WINTERS A C, BERNT K M. MLL-rearranged leukemias-an update on science and clinical approaches[J]. Front Pediatr, 2017, 5:4. DOI PMID
[11]	LIU H, WESTERGARD T D, CASHEN A, et al. Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4[J]. Cancer Cell, 2014, 25(4):530-542. DOI PMID
[12]	JO S Y, GRANOWICZ E M, MAILLARD I, et al. Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation[J]. Blood, 2011, 117(18):4759-4768. DOI PMID
[13]	LENARD A, XIE H M, PASTUER T, et al. Epigenetic regulation of protein translation in KMT2A-rearranged AML[J]. Exp Hematol, 2020, 85:57-69. DOI PMID
[14]	CHEN X, WANG F, ZHANG Y, et al. Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients[J]. Leuk Lymphoma, 2019, 60(4):1071-1078. DOI URL
[15]	QIU L, NUNEZ C A, TANG G, et al. A rare case of acute megakaryoblastic leukemia with t(11;17)(q23;q21)and KMT2A:MLLT6 fusion[J]. Ann Hematol, 2022, 101(7):1579-1581. DOI

病例	性别	年龄/岁	AML分型	外周血检测结果
病例	性别	年龄/岁	AML分型	白细胞计数/ （×10⁹/L）	血小板计数/ （×10⁹/L）	血红蛋白/ （g/L）	原始细胞比例/ %
病例1（本病例）	男	43	M5	57.12	78	150.0	69
病例2^[5]	男	40	M5	30.50	82	121.0	54
病例3^[6]	女	45	M5	162.00	83	10.0	97
病例4^[6]	男	19	M5	1.30	152	4.8	4

病例	性别	年龄/岁	AML分型	外周血检测结果
病例	性别	年龄/岁	AML分型	白细胞计数/ （×10⁹/L）	血小板计数/ （×10⁹/L）	血红蛋白/ （g/L）	原始细胞比例/ %
病例1（本病例）	男	43	M5	57.12	78	150.0	69
病例2^[5]	男	40	M5	30.50	82	121.0	54
病例3^[6]	女	45	M5	162.00	83	10.0	97
病例4^[6]	男	19	M5	1.30	152	4.8	4

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 3

References 15

Related Articles 15

Recommended Articles

Metrics

[1]	GAO Zikang, CHEN Jing. Construction of a nomogram prediction model for the prognosis of patients with depressive disorder based on the characteristics of peripheral blood lymphocyte subsets [J]. Laboratory Medicine, 2025, 40(12): 1146-1152.
[2]	WANG Tian, ZHANG Yun, BAI Yi, ZHAI Weibin, ZHAO Hai. Roles of PIV，SII and NPAR in the diagnosis of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites [J]. Laboratory Medicine, 2025, 40(12): 1153-1158.
[3]	HUANG Ting, XU Yan, SHI Qingxing, PENG Ying. Roles of miR-944 and MARCH7 mRNA in prognosis assessment of non-small cell lung cancer patients [J]. Laboratory Medicine, 2025, 40(12): 1159-1164.
[4]	LI Minghong, MIN Cuili, GUO Qingbo, MA Lujuan. Predictive roles of serum 25（OH）D and SAA for the response to immunosuppressive therapy in autoimmune hepatitis [J]. Laboratory Medicine, 2025, 40(12): 1165-1170.
[5]	ZHEN Di, JIA Bin, MENG Xianyi. Roles of serum sPD-1 and sTWEAK levels in patients with ulcerative colitis in disease monitoring and prognosis assessment [J]. Laboratory Medicine, 2025, 40(12): 1171-1176.
[6]	ZHAO Yilin, XU Yan, YIN Hui. Roles of serum miR-145-5p，miR-200C-3p and miR-1290 in prognosis assessment of patients with papillary thyroid carcinoma [J]. Laboratory Medicine, 2025, 40(12): 1177-1182.
[7]	LI Song, XIANG Xu. Risk factors for poor prognosis in elderly patients with severe fever and thrombocytopenia syndrome and their clinical significance [J]. Laboratory Medicine, 2025, 40(12): 1183-1189.
[8]	CHANG Nan, WEI Yali, LU Qifeng, LI Tian, HOU Tingting, LI Yuan, ZHU Mengyu, SHEN Yajuan. A machine learning early warning model for acute promyelocytic leukemia based on blood cell analyzer parameters [J]. Laboratory Medicine, 2025, 40(12): 1190-1196.
[9]	. [J]. Laboratory Medicine, 2025, 40(12): 1197-1202.
[10]	. [J]. Laboratory Medicine, 2025, 40(12): 1216-1221.
[11]	. [J]. Laboratory Medicine, 2025, 40(12): 1222-1226.
[12]	BAO Wen. Application and prospect of microsatellite instability determination in tumor diagnosis and treatment [J]. Laboratory Medicine, 2025, 40(12): 1227-1231.
[13]	XIONG Ying, GUO Wei. From generic to personalized：the evolution and frontiers of indirect methods for establishing reference interval [J]. Laboratory Medicine, 2025, 40(11): 1035-1041.
[14]	CHEN Yanqin, FAN Lina, YANG Dagan. Six indirect method algorithms for establishing the reference range of serum cystatin C for adults in Hangzhou and consistency analysis [J]. Laboratory Medicine, 2025, 40(11): 1047-1052.
[15]	LIU Chunyan, NIU Shumin, DENG Zhaohui, LIANG Mengjie, ZHANG Xin. Establishing the reference ranges for AFP，CEA，CA72-4 and CA19-9 in Urumqi region by indirect method [J]. Laboratory Medicine, 2025, 40(11): 1053-1058.