Abstract:

Objective To investigate the relationship between plasma adiponectin（APN）,soluble receptor for advanced glycation end product（sRAGE） and the prognosis of patients with acute respiratory distress syndrome（ARDS）. Methods A total of 120 ARDS patients treated in intensive care unit（ICU） were enrolled,which included 21 mild patients（mild group）,56 moderate patients（moderate group） and 43 severe patients（severe group）. Oxygenation index,acute physiology and chronic health evaluation Ⅱ（APACHE Ⅱ） score,sequential organ failure assessment（SOFA） score and lung injury score（LIS） at 1 h after admission were recorded,and the plasma levels of APN and sRAGE were determined. All the patients were followed up for 12 months to calculate the mortality. Logistic regression analysis was used to evaluate the risk factors of death in patients with ARDS. Results The levels of APN in mild group,moderate group and severe group decreased in turn（P<0.05）,and the levels of sRAGE in plasma increased in turn（P<0.05）. Among the 120 ARDS patients,32（26.67%） died. The oxygenation index and plasma APN level of death group were lower than those of survival group（P<0.05）,and the APACHE Ⅱ score,SOFA score,LIS and plasma sRAGE level of death group were higher than those of survival group（P<0.05）. APACHE Ⅱ score,SOFA score,APN and sRAGE were the risk factors of death in ARDS patients [odds ratio（OR） were 1.723,1.652,0.754 and 1.391,95% confidence intervals（CI） were 1.206-2.461,1.110-2.459,0.624-0.912 and 1.117-1.732,respectively]. Conclusions APN and sRAGE are related to the severity and prognosis of ARDS,which can be used as the indicators to evaluate the severity and prognosis of ARDS.

Key words: Adiponectin, Soluble receptor for advanced glycation end product, Acute respiratory distress syndrome, Prognosis