Laboratory Medicine ›› 2023, Vol. 38 ›› Issue (10): 930-935.DOI: 10.3969/j.issn.1673-8640.2023.10.005
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ZHOU Jun1, LI Liheng2, ZHANG Min3
Received:
2021-11-05
Revised:
2023-05-31
Online:
2023-10-30
Published:
2023-12-18
CLC Number:
ZHOU Jun, LI Liheng, ZHANG Min. Expressions of serum miR-24 and XIAP mRNA in serum of oral adenoid cystic carcinoma patients and relationship with prognosis[J]. Laboratory Medicine, 2023, 38(10): 930-935.
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基因 | 正向引物(5'~3' ) | 反向引物(5'~3') |
---|---|---|
miR-24 | GCCTACTGAGCTGAAAC | GAACATGTCTGCGTATCTC |
U6 | CTCGCTTCGGCAGCACA | AACGCTTCACGAATTTGCGT |
XIAP | CATCCATGGCAGATTATGAAGCA | CTTCACTGGGCTTCCAATCAGTTAG |
GAPDH | GCACCGTCAAGGCTGAGAAC | TGGTGAAGACGCCAGTGGA |
基因 | 正向引物(5'~3' ) | 反向引物(5'~3') |
---|---|---|
miR-24 | GCCTACTGAGCTGAAAC | GAACATGTCTGCGTATCTC |
U6 | CTCGCTTCGGCAGCACA | AACGCTTCACGAATTTGCGT |
XIAP | CATCCATGGCAGATTATGAAGCA | CTTCACTGGGCTTCCAATCAGTTAG |
GAPDH | GCACCGTCAAGGCTGAGAAC | TGGTGAAGACGCCAGTGGA |
组别 | 例数 | 年龄 | 性别 | 肿瘤大小 | 淋巴转移 | 神经侵袭 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<60岁 | ≥60岁 | 男 | 女 | <4 cm | ≥4 cm | 有 | 无 | 有 | 无 | ||||||
miR-24低表达组 | 32 | 19 | 13 | 14 | 18 | 18 | 14 | 24 | 8 | 21 | 11 | ||||
miR-24高表达组 | 28 | 16 | 12 | 10 | 18 | 15 | 13 | 7 | 21 | 9 | 19 | ||||
χ2值 | 0.031 | 0.402 | 0.043 | 14.950 | 6.696 | ||||||||||
P值 | 0.861 | 0.526 | 0.835 | <0.001 | <0.001 |
组别 | 例数 | 年龄 | 性别 | 肿瘤大小 | 淋巴转移 | 神经侵袭 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<60岁 | ≥60岁 | 男 | 女 | <4 cm | ≥4 cm | 有 | 无 | 有 | 无 | ||||||
miR-24低表达组 | 32 | 19 | 13 | 14 | 18 | 18 | 14 | 24 | 8 | 21 | 11 | ||||
miR-24高表达组 | 28 | 16 | 12 | 10 | 18 | 15 | 13 | 7 | 21 | 9 | 19 | ||||
χ2值 | 0.031 | 0.402 | 0.043 | 14.950 | 6.696 | ||||||||||
P值 | 0.861 | 0.526 | 0.835 | <0.001 | <0.001 |
组别 | 例数 | 年龄 | 性别 | 肿瘤大小 | 淋巴转移 | 神经侵袭 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<60岁 | ≥60岁 | 男 | 女 | <4 cm | ≥4 cm | 有 | 无 | 有 | 无 | ||||||
XIAP低表达组 | 29 | 17 | 12 | 12 | 17 | 16 | 13 | 3 | 26 | 10 | 19 | ||||
XIAP高表达组 | 31 | 18 | 13 | 12 | 19 | 17 | 14 | 20 | 11 | 20 | 11 | ||||
χ2值 | 0.002 | 0.044 | 0.001 | 16.600 | 5.406 | ||||||||||
P值 | 0.965 | 0.833 | 0.979 | 0.001 | 0.020 |
组别 | 例数 | 年龄 | 性别 | 肿瘤大小 | 淋巴转移 | 神经侵袭 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<60岁 | ≥60岁 | 男 | 女 | <4 cm | ≥4 cm | 有 | 无 | 有 | 无 | ||||||
XIAP低表达组 | 29 | 17 | 12 | 12 | 17 | 16 | 13 | 3 | 26 | 10 | 19 | ||||
XIAP高表达组 | 31 | 18 | 13 | 12 | 19 | 17 | 14 | 20 | 11 | 20 | 11 | ||||
χ2值 | 0.002 | 0.044 | 0.001 | 16.600 | 5.406 | ||||||||||
P值 | 0.965 | 0.833 | 0.979 | 0.001 | 0.020 |
项目 | 单因素分析 | 多因素分析 | |||||
---|---|---|---|---|---|---|---|
HR①值 | 95%CI② | P值 | HR①值 | 95%CI② | P值 | ||
淋巴转移(无转移与转移) | 1.896 | 1.309~2.746 | <0.001 | 1.140 | 0.912~1.425 | 0.250 | |
神经侵袭(无与有) | 1.992 | 1.349~2.942 | <0.001 | 1.835 | 1.252~2.689 | 0.002 | |
miR-24(低表达与高表达) | 0.453 | 0.372~0.552 | <0.001 | 0.508 | 0.415~0.622 | <0.001 | |
XIAP mRNA(低表达与高表达) | 2.061 | 1.376~3.086 | <0.001 | 1.922 | 1.319~2.800 | 0.001 |
项目 | 单因素分析 | 多因素分析 | |||||
---|---|---|---|---|---|---|---|
HR①值 | 95%CI② | P值 | HR①值 | 95%CI② | P值 | ||
淋巴转移(无转移与转移) | 1.896 | 1.309~2.746 | <0.001 | 1.140 | 0.912~1.425 | 0.250 | |
神经侵袭(无与有) | 1.992 | 1.349~2.942 | <0.001 | 1.835 | 1.252~2.689 | 0.002 | |
miR-24(低表达与高表达) | 0.453 | 0.372~0.552 | <0.001 | 0.508 | 0.415~0.622 | <0.001 | |
XIAP mRNA(低表达与高表达) | 2.061 | 1.376~3.086 | <0.001 | 1.922 | 1.319~2.800 | 0.001 |
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