Reference interval of lactate dehydrogenase among 3-14-year-old population in Hainan

doi:10.3969/j.issn.1673-8640.2023.11.007

Abstract

Abstract:

Objective To establish the reference interval of lactate dehydrogenase（LDH） among 3-14-year-old population in Hainan. Methods A total of 36 945 subjects of 3-14-year-old were enrolled from December 2020 to September 2021，and serum LDH was determined. According to age and sex，the reference interval of LDH in 3-14-year-old population was established by percentile method. The difference between established reference interval and adult LDH reference interval was compared. Results There was statistical significance for age in 3-14-year-old population（P<0.001）. There was statistical significance in LDH levels between males and females of 6-14-year-old（P<0.05）. LDH reference intervals of different ages and sex were established. The established LDH reference interval of 3-14-year-old population had statistical significance from that of adults（P<0.001）. Conclusions The LDH reference interval of 3-14-year-old population has been established. The current LDH reference interval for adults is not applicable to 3-14-year-old population.

Key words: Lactate dehydrogenase, 3-14-Year-old population, Children and adolescents, Reference interval, Hainan

CLC Number:

Q554

ZHAO Yanhong, FU Lin, LIU Biao, XIAO Meifang. Reference interval of lactate dehydrogenase among 3-14-year-old population in Hainan[J]. Laboratory Medicine, 2023, 38(11): 1041-1043.

Figures/Tables 2

References 13

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年龄	例数	LDH/（U/L）	男性		女性		不同性别比较
年龄	例数	LDH/（U/L）	例数	LDH/（U/L）	例数	LDH/（U/L）	Z值	P值
3岁	462	272（234~314）	236	281（237~320）	226	269（231~307）	-1.777	0.076
4岁	629	264（224~294）	332	262（221~293）	297	266（225~296）	-0.729	0.466
5岁	616	256（224~287）^*	339	257（228~294）	277	254（221~285）	-1.636	0.102
6岁	3 714	261（235~288）^*#	1 869	264（238~291）	1 845	258（231~284）	-5.439	<0.001
7岁	5 292	257（231~286）^*#	2 698	259（234~289）	2 594	255（228~283）	-4.111	<0.001
8岁	5 397	255（229~283）^*#△▲	2 720	259（232~285）	2 677	252（227~280）	-4.958	<0.001
9岁	5 592	250（225~277）^*#▲□■	2 799	254（228~282）	2 793	245（221~272）	-8.040	<0.001
10岁	5 422	245（218~272）^{*#△▲□■◇}	2 714	254（227~280）	2 708	236（212~263）	-15.375	<0.001
11岁	5 248	236（209~265）^{*#△▲□■◇◆}	2 638	250（225~278）	2 610	220（199~247）	-24.516	<0.001
12岁	2 088	231（205~259）^{*#△▲□■◇◆○}	1 084	247（221~274）	1 004	215（194~239）	-17.714	<0.001
13岁	1 273	218（192~250）^{*#△▲□■◇◆○●}	593	235（210~267）	680	205（181~230）	-12.944	<0.001
14岁	1 212	211（189~240）^{*#△▲□■◇◆○●☆}	575	220（199~249）	637	202（180~227）	-8.468	<0.001

年龄	例数	LDH/（U/L）	男性		女性		不同性别比较
年龄	例数	LDH/（U/L）	例数	LDH/（U/L）	例数	LDH/（U/L）	Z值	P值
3岁	462	272（234~314）	236	281（237~320）	226	269（231~307）	-1.777	0.076
4岁	629	264（224~294）	332	262（221~293）	297	266（225~296）	-0.729	0.466
5岁	616	256（224~287）^*	339	257（228~294）	277	254（221~285）	-1.636	0.102
6岁	3 714	261（235~288）^*#	1 869	264（238~291）	1 845	258（231~284）	-5.439	<0.001
7岁	5 292	257（231~286）^*#	2 698	259（234~289）	2 594	255（228~283）	-4.111	<0.001
8岁	5 397	255（229~283）^*#△▲	2 720	259（232~285）	2 677	252（227~280）	-4.958	<0.001
9岁	5 592	250（225~277）^*#▲□■	2 799	254（228~282）	2 793	245（221~272）	-8.040	<0.001
10岁	5 422	245（218~272）^{*#△▲□■◇}	2 714	254（227~280）	2 708	236（212~263）	-15.375	<0.001
11岁	5 248	236（209~265）^{*#△▲□■◇◆}	2 638	250（225~278）	2 610	220（199~247）	-24.516	<0.001
12岁	2 088	231（205~259）^{*#△▲□■◇◆○}	1 084	247（221~274）	1 004	215（194~239）	-17.714	<0.001
13岁	1 273	218（192~250）^{*#△▲□■◇◆○●}	593	235（210~267）	680	205（181~230）	-12.944	<0.001
14岁	1 212	211（189~240）^{*#△▲□■◇◆○●☆}	575	220（199~249）	637	202（180~227）	-8.468	<0.001

年龄	总体	男性	女性
3岁	154~442
4岁	156~404
5岁	142~361
6岁	153~358	155~369	150~349
7岁	158~366	163~371	153~361
8岁	174~363	175~365	170~361
9岁	167~356	168~370	166~350
10岁	163~347	166~359	162~326
11岁	158~341	166~357	155~315
12岁	152~341	168~355	147~324
13岁	148~365	156~374	143~359
14岁	148~336	153~341	147~335

年龄	总体	男性	女性
3岁	154~442
4岁	156~404
5岁	142~361
6岁	153~358	155~369	150~349
7岁	158~366	163~371	153~361
8岁	174~363	175~365	170~361
9岁	167~356	168~370	166~350
10岁	163~347	166~359	162~326
11岁	158~341	166~357	155~315
12岁	152~341	168~355	147~324
13岁	148~365	156~374	143~359
14岁	148~336	153~341	147~335

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