Relationship between neutrophil/lymphocyte ratio，fibrinogen and carotid intima-media thickness in type 2 diabetes mellitus patients

doi:10.3969/j.issn.1673-8640.2023.04.013

Abstract

Abstract:

Objective To evaluate the relationship between neutrophil/lymphocyte ratio（NLR），fibrinogen（Fib） and carotid intima-media thickness（CIMT） in patients with type 2 diabetes mellitus. Methods Totally，327 patients with type 2 diabetes mellitus from Suqian First People's Hospital of Nanjing Medical University from January 2019 to April 2020 were enrolled and classified into normal CIMT group（116 cases），thickened CIMT group（38 cases） and plaque group（173 cases），according to CIMT. The differences of general data，blood routine test results and biochemical indicator determination results among the 3 groups were compared. Logistic regression analysis was used to analyze the risk factors for CIMT abnormalities in type 2 diabetes mellitus，and receiver operating characteristic（ROC） curves were used for the diagnosis efficiency of CIMT abnormalities. Results There was no statistical significance in sex，body mass index，diastolic blood pressure，renal function，blood lipid，white blood cell count，prothrombin time and international normalized ratio（INR） among normal CIMT，thickened CIMT and plaque 3 groups（P>0.05）. Compared with normal CIMT group，there was statistical significance in age，NLR and Fib in thickened CIMT group and plaque group（P<0.05）. Compared with normal CIMT group，diabetes mellitus disease course，systolic blood pressure and lymphocyte count in plaque group had statistical significance（P<0.05），and neutrophil count and glycated hemoglobin in thickened CIMT group had statistical significance（P<0.05）. Age，systolic blood pressure，NLR and Fib were risk factors for CIMT abnormality in type 2 diabetes mellitus patients [odds ratios（OR） were 1.062，1.041，1.285 and 1.477，P<0.05]. The areas under curves of NLR and Fib for diagnosing CIMT abnormality were 0.588 and 0.604，respectively（P<0.05）. Conclusions NLR and Fib play roles in screening and the diagnosis of CIMT abnormality.

Key words: Neutrophil/lymphocyte ratio, Fibrinogen, Carotid intima-media thickness, Type 2 diabetes mellitus

CLC Number:

R446.1

DENG Xu, ZHUANG Wenlong, XUE Hui, ZHU Shuqin, LI Ying. Relationship between neutrophil/lymphocyte ratio，fibrinogen and carotid intima-media thickness in type 2 diabetes mellitus patients[J]. Laboratory Medicine, 2023, 38(4): 368-372.

Figures/Tables 3

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组别	例数	年龄/岁	性别		糖尿病病程/年	体重指数/（kg/m²）	收缩压/ kPa	舒张压/ kPa
组别	例数	年龄/岁	男/[例（%）]	女/[例（%）]	糖尿病病程/年	体重指数/（kg/m²）	收缩压/ kPa	舒张压/ kPa
CIMT正常组	116	48.75±11.58	69（59.5）	47（40.5）	4.56±5.04	25.78±3.37	17.6±2.3	10.9±1.6
CIMT增厚组	38	55.68±9.54^*	20（52.6）	18（47.4）	6.70±5.82	26.01±3.87	17.1±2.1	10.7±1.4
斑块组	173	57.69±10.65^*	99（57.2）	74（42.8）	7.30±7.69^*	25.70±3.69	18.4±2.4^*	10.8±1.6
统计值		23.846	0.560		5.981	0.118	7.369	0.153
P值		<0.01	0.756		<0.01	0.888	<0.01	0.858
组别	糖化血红蛋白/%	肌酐/（μmol/L）	尿酸/（μmol/L）		总胆固醇/（mmol/L）	三酰甘油/（mmol/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
CIMT正常组	9.91±2.16	55.51±13.31	273.4±81.3		5.17±1.26	2.62±3.16	1.17±0.30	3.31±0.82
CIMT增厚组	10.84±2.45^*	54.30±12.29	262.7±75.4		5.33±1.23	1.82±1.36	1.19±0.33	3.50±0.79
斑块组	10.16±2.17	56.32±17.75	258.7±79.4		5.18±1.56	2.15±2.47	1.21±0.51	4.21±10.82
统计值	2.475	0.278	1.142		1.177	1.676	0.255	0.462
P值	<0.05	0.758	0.320		0.838	0.189	0.775	0.631
组别	血细胞				NLR	凝血酶原时间/s	INR	Fib/（g/L）
组别	白细胞计数/ （×10⁹/L）	中性粒细胞计数/（×10⁹/L）	淋巴细胞计数/（×10⁹/L）		NLR	凝血酶原时间/s	INR	Fib/（g/L）
CIMT正常组	6.10±1.82	3.45±1.30	2.07±0.69		1.82±0.90	11.44±1.18	0.99±0.11	2.64±0.72
CIMT增厚组	6.47±1.45	3.97±1.13^*	1.92±0.64		2.32±1.04^*	11.14±1.08	0.97±0.10	3.04±0.70^*
斑块组	6.26±1.75	3.76±1.41	1.90±0.65^*		2.22±1.33^*	11.35±1.17	1.05±0.78	2.85±0.75^*
统计值	0.703	2.689	2.225		4.815	0.873	0.457	4.564
P值	0.496	<0.05	<0.05		<0.05	0.419	0.634	<0.05

组别	例数	年龄/岁	性别		糖尿病病程/年	体重指数/（kg/m²）	收缩压/ kPa	舒张压/ kPa
组别	例数	年龄/岁	男/[例（%）]	女/[例（%）]	糖尿病病程/年	体重指数/（kg/m²）	收缩压/ kPa	舒张压/ kPa
CIMT正常组	116	48.75±11.58	69（59.5）	47（40.5）	4.56±5.04	25.78±3.37	17.6±2.3	10.9±1.6
CIMT增厚组	38	55.68±9.54^*	20（52.6）	18（47.4）	6.70±5.82	26.01±3.87	17.1±2.1	10.7±1.4
斑块组	173	57.69±10.65^*	99（57.2）	74（42.8）	7.30±7.69^*	25.70±3.69	18.4±2.4^*	10.8±1.6
统计值		23.846	0.560		5.981	0.118	7.369	0.153
P值		<0.01	0.756		<0.01	0.888	<0.01	0.858
组别	糖化血红蛋白/%	肌酐/（μmol/L）	尿酸/（μmol/L）		总胆固醇/（mmol/L）	三酰甘油/（mmol/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
CIMT正常组	9.91±2.16	55.51±13.31	273.4±81.3		5.17±1.26	2.62±3.16	1.17±0.30	3.31±0.82
CIMT增厚组	10.84±2.45^*	54.30±12.29	262.7±75.4		5.33±1.23	1.82±1.36	1.19±0.33	3.50±0.79
斑块组	10.16±2.17	56.32±17.75	258.7±79.4		5.18±1.56	2.15±2.47	1.21±0.51	4.21±10.82
统计值	2.475	0.278	1.142		1.177	1.676	0.255	0.462
P值	<0.05	0.758	0.320		0.838	0.189	0.775	0.631
组别	血细胞				NLR	凝血酶原时间/s	INR	Fib/（g/L）
组别	白细胞计数/ （×10⁹/L）	中性粒细胞计数/（×10⁹/L）	淋巴细胞计数/（×10⁹/L）		NLR	凝血酶原时间/s	INR	Fib/（g/L）
CIMT正常组	6.10±1.82	3.45±1.30	2.07±0.69		1.82±0.90	11.44±1.18	0.99±0.11	2.64±0.72
CIMT增厚组	6.47±1.45	3.97±1.13^*	1.92±0.64		2.32±1.04^*	11.14±1.08	0.97±0.10	3.04±0.70^*
斑块组	6.26±1.75	3.76±1.41	1.90±0.65^*		2.22±1.33^*	11.35±1.17	1.05±0.78	2.85±0.75^*
统计值	0.703	2.689	2.225		4.815	0.873	0.457	4.564
P值	0.496	<0.05	<0.05		<0.05	0.419	0.634	<0.05

自变量	β值	P值	OR值	95%可信区间
年龄	-0.060	0.000	1.062	1.027~1.097
收缩压	-0.035	0.000	1.041	1.018~1.064
NLR	0.251	0.011	1.285	1.085~1.677
Pib	0.390	0.010	1.477	1.098~1.185

自变量	β值	P值	OR值	95%可信区间
年龄	-0.060	0.000	1.062	1.027~1.097
收缩压	-0.035	0.000	1.041	1.018~1.064
NLR	0.251	0.011	1.285	1.085~1.677
Pib	0.390	0.010	1.477	1.098~1.185

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