Relationship between four coagulation factors and C peptide and IR in T2DM patients with microangiopathy

doi:10.3969/j.issn.1673-8640.2020.04.009

Abstract

Abstract:

Objective To analyze the relationship between four coagulation factors [prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）and fibrinogen（Fib）] and C peptide and insulin resistance（IR） in type 2 diabetes mellitus（T2DM）patients with microangiopathy. Methodse A total of 100 T2DM patients with microangiopathy were enrolled as observation group,and 100 T2DM patients without microangiopathy were enrolled as control group. PT,APTT,TT,Fib,C peptide and IR levels were determined. Pearson correlation analysis was used to analyze the correlation between four coagulation factors and C peptide and IR levels. Results The levels of PT,APTT,TT and C peptide in observation group were lower than those in control group（P<0.001）,and the level of Fib and homeostasis mode assessment for insulin resistance（HOMA-IR） in observation group were higher than those in control group（P<0.001）. C peptide was positively correlated with PT and APTT（r=0.302 and 0.224,P<0.05）,and IR was negatively correlated with PT and APTT（r=-0.413 and -0.253,P<0.05）. Conclusions The coagulation dysfunction of T2DM patients with microangiopathy is related to the decreasing of C peptide and the increasing of IR.

Key words: Type 2 diabetes mellitus, Microangiopathy, Four coagulation factors, C peptide, Insulin resistance

CLC Number:

R446.1

ZUO Xuecan, CHU Yanling, LI Zhanping. Relationship between four coagulation factors and C peptide and IR in T2DM patients with microangiopathy[J]. Laboratory Medicine, 2020, 35(4): 327-328.

Figures/Tables 1

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组别	例数	PT/s	APTT/s	TT/s	Fib/（g/L）	C肽/（mmol/L）	HOMA-IR
观察组	100	12.09±0.36	25.12±0.89	15.55±0.21	341.82±20.19	1.41±0.32	5.44±0.65
对照组	100	12.54±0.31	27.12±0.85	15.98±0.32	270.32±21.18	1.87±0.29	4.11±0.42
t值		7.109	12.970	8.561	33.372	7.603	12.402
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	PT/s	APTT/s	TT/s	Fib/（g/L）	C肽/（mmol/L）	HOMA-IR
观察组	100	12.09±0.36	25.12±0.89	15.55±0.21	341.82±20.19	1.41±0.32	5.44±0.65
对照组	100	12.54±0.31	27.12±0.85	15.98±0.32	270.32±21.18	1.87±0.29	4.11±0.42
t值		7.109	12.970	8.561	33.372	7.603	12.402
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

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