Role of brown adipose tissue in insulin resistance and its research progress

doi:10.3969/j.issn.1673-8640.2023.03.019

Abstract

Abstract:

Brown adipose tissue is a kind of special fat in mammals，which is composed of brown adipocytes and stromal vascular fraction. It is involved in glucose and lipid metabolism and plays a role in insulin resistance（IR）. The thermogenic effect of brown adipocytes increases energy consumption，and secretary factors from brown adipocytes act in autocrine or paracrine forms in multiple tissues to regulate energy consumption，feeding behavior and insulin sensitivity. In this review，the function and secretion factors of brown adipose tissue are summarized. The research progress of brown adipose tissue in animal model and human body is summarized. The effect brown adipose tissue on IR improvement is discussed.

Key words: Brown adipose tissue, Insulin resistance, Uncoupling protein 1, Glucose metabolism

CLC Number:

R446.1

SUN Wenyuan, WANG Pan, CUI Liyan. Role of brown adipose tissue in insulin resistance and its research progress[J]. Laboratory Medicine, 2023, 38(3): 297-300.

References 31

[1]	WANG L, WANG S, SHI Y, et al. YAP and TAZ protect against white adipocyte cell death during obesity[J]. Nat Commun, 2020, 11(1):5455. DOI PMID
[2]	IKEDA K, YAMADA T. UCP1 dependent and independent thermogenesis in brown and beige adipocytes[J]. Front Endocrinol(Lausanne), 2020, 11:498.
[3]	ORMAZABAL V, NAIR S, ELFEKY O, et al. Association between insulin resistance and the development of cardiovascular disease[J]. Cardiovasc Diabetol, 2018, 17(1):122. DOI PMID
[4]	FRIGOLET M E, GUTIÉRREZ-AGUILAR R. The role of the novel lipokine palmitoleic acid in health and disease[J]. Adv Nutr, 2017, 8(1):173S-181S. DOI URL
[5]	MIAO Z, ALVAREZ M, KO A, et al. The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance[J]. PLoS Genet, 2020, 16(9):e1009018. DOI URL
[6]	陈宏锦, 潘晓茜, 高平进, 等. 棕色脂肪组织与心血管疾病的关系[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(3):182-186.
[7]	BECHER T, PALANISAMY S, KRAMER D J, et al. Brown adipose tissue is associated with cardiometabolic health[J]. Nat Med, 2021, 27(1):58-65. DOI PMID
[8]	NISHIMURA T, MOTOI M, EGASHIRA Y, et al. Seasonal variation of non-shivering thermogenesis(NST) during mild cold exposure[J]. J Physiol Anthropol, 2015, 34(1):11. DOI URL
[9]	FISCHER A W, BEHRENS J, SASS F, et al. Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice[J]. J Lipid Res, 2020, 61(11):1377-1389. DOI PMID
[10]	HARMS M, SEALE P. Brown and beige fat:development,function and therapeutic potential[J]. Nat Med, 2013, 19(10):1252-1263. DOI
[11]	ASSEFA B, MAHMOUD A M, PFEIFFER A F H, et al. Insulin-like growth factor(IGF) binding protein-2,independently of IGF-1,induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes[J]. Oxid Med Cell Longev, 2017, 2017:3035184.
[12]	GHARANEI S, SHABIR K, BROWN J E, et al. Regulatory microRNAs in brown,brite and white adipose tissue[J]. Cells, 2020, 9(11):2489. DOI URL
[13]	MÖSSENBÖCK K, VEGIOPOULOS A, ROSE A J, et al. Browning of white adipose tissue uncouples glucose uptake from insulin signaling[J]. PLoS One, 2014, 9(10):e110428. DOI URL
[14]	KWON H J, SAHA A, AHN SY, et al. Polymethoxyselenoflavones exert anti-obesity effects through activation of lipolysis and brown adipocyte metabolism[J]. Int J Obes(Lond), 2021, 45(1):122-129. DOI
[15]	OLSEN J M, SATO M, DALLNER O S, et al. Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation[J]. J Cell Biol, 2014, 207(3):365-374. DOI PMID
[16]	LEITNER B P, HUANG S, BRYCHTA R J, et al. Mapping of human brown adipose tissue in lean and obese young men[J]. Proc Natl Acad Sci U S A, 2017, 114(32):8649-8654. DOI URL
[17]	GÓMEZ-HERNÁNDEZ A, OTERO Y F, DE LAS HERAS N, et al. Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction[J]. Endocrinology, 2012, 153(3):1242-1255. DOI URL
[18]	MESA A M, MEDRANO T I, SIROHI V K, et al. Identification and characterization of novel abdominal and pelvic brown adipose depots in mice[J]. Adipocyte, 2022, 11(1):616-629. DOI PMID
[19]	LIU D, BORDICCHIA M, ZHANG C, et al. Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning[J]. J Clin Invest, 2016, 126(5):1704-1716. DOI PMID
[20]	HANSSEN M J, WIERTS R, HOEKS J, et al. Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance[J]. Diabetologia, 2015, 58(3):586-595. DOI PMID
[21]	SOUNDARRAJAN M, DENG J, KWASNY M, et al. Activated brown adipose tissue and its relationship to adiposity and metabolic markers:an exploratory study[J]. Adipocyte, 2020, 9(1):87-95. DOI URL
[22]	刘玲, 刘思佳, 刘洋, 等. PAQR9对棕色脂肪产热及UCP1表达的影响[J]. 复旦学报(医学版), 2020, 47(6):816-824.
[23]	RUI L. Brown and beige adipose tissues in health and disease[J]. Compr Physiol, 2017, 7(4):1281-1306. DOI PMID
[24]	武晓慧, 李青, 魏婉丽, 等. Jmjd3维持小鼠棕色脂肪细胞脂滴及线粒体的形态和功能[J]. 中南大学学报(医学版), 2020, 45(11):1298-1307.
[25]	CARPENTIER A C, BLONDIN D P, VIRTANEN K A, et al. Brown adipose tissue energy metabolism in humans[J]. Front Endocrinol(Lausanne), 2018, 9:447.
[26]	PAYAB M, ABEDI M, FOROUGHI HERAVANI N, et al. Brown adipose tissue transplantation as a novel alternative to obesity treatment:a systematic review[J]. Int J Obes(Lond), 2021, 45(1):109-121. DOI
[27]	ROSELL M, KAFOROU M, FRONTINI A, et al. Brown and white adipose tissues:intrinsic differences in gene expression and response to cold exposure in mice[J]. Am J Physiol Endocrinol Metab, 2014, 306(8):E945-E964. DOI URL
[28]	VILLARROYA J, CEREIJO R, VILLARROYA F. An endocrine role for brown adipose tissue?[J]. Am J Physiol Endocrinol Metab, 2013, 305(5):E567-E572. DOI URL
[29]	MA Y, GAO M, LIU D. Preventing high fat diet-induced obesity and improving insulin sensitivity through neuregulin 4 gene transfer[J]. Sci Rep, 2016, 6:26242. DOI PMID
[30]	CHEN Z, WANG G X, MA S L, et al. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders[J]. Mol Metab, 2017, 6(8):863-872. DOI PMID
[31]	葛李娜, 杨进, 洪天配. 成纤维细胞生长因子21在血糖调节中的作用及其治疗学意义[J]. 中华糖尿病杂志, 2018, 10(6):4.