The relationships between the serum levels of resistin and insulin resistance among pregnant women with gestational diabetes mellitus in mid-pregnancy

doi:10.3969/j.issn.1673-8640.2014.09.012

Abstract

Abstract: Objective To investigate the relationships between the serum levels of resistin and insulin resistance(IR) among pregnant women with gestational diabetes mellitus (GDM) in mid-pregnancy and its role in the progress of GDM. Methods A total of 98 GDM pregnant women (24-28 weeks) were enrolled as GDM group, and 95 healthy pregnant women (24-28 weeks) at the same period were enrolled as control group. The serum levels of resistin, fasting blood glucose(FBG) and fasting insulin(FINS) of all pregnant women were determined by enzyme-linked immunosorbent assay (ELISA), glucose oxidase method and electrochemiluminescence immunoassay, respectively. The home model insulin resistance index(HOMA-IR) was calculated. The difference of serum resistin and IR levels in the 2 groups were compared. The correlations between serum resistin and IR levels were analyzed. Results The serum levels of resistin, FBG, FINS and HOMA-IR in GDM group were (19.74±6.89)μg/mL, (5.35±1.23)mmol/L, (21.77±7.83)mU/L and 5.24±2.65, and those in control group were (15.62±4.19)μg/mL, (4.34±0.43)mmol/L, (17.81±4.92)mU/L and 3.43±1.00 (P<0.05). The serum levels of resistin were positively correlated with HOMA-IR(r=0.459, P<0.05). Conclusions The serum levels of resistin are closely correlated with HOMA-IR. Resistin probably plays its role in the progress of GDM.

Key words: Resistin, Insulin resistance, Gestational diabetes mellitus

CLC Number:

R446.1

KE Huihui, GUO Limei, DING Haiying, XU Yiqun, GU Jiashi, YAN Yuzhong, YANG Xiaoning. The relationships between the serum levels of resistin and insulin resistance among pregnant women with gestational diabetes mellitus in mid-pregnancy[J]. , 2014, 29(9): 921-924.

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