Research progress on molecular pathogenesis of obesity-induced insulin resistance

doi:10.3969/j.issn.1673-8640.2014.07.019

Abstract

Abstract:

Insulin resistance（IR） is defined as a pathophysiological condition in which normal insulin concentration does not adequately produce a normal insulin response in target tissues. It is well established that obesity and body fat distribution are associated with the increasing rate of IR. Obesity is a common cause of cardiovascular and hepatic diseases， and often precedes the onset of hyperglycemia and predicts the development of type 2 diabetes mellitus based on IR. Free fatty acids（FFA）， inflammation and oxidative stress play key roles in the development and progression of IR induced by obesity.

Key words: Insulin resistance, Obesity, Free fatty acid, Inflammation, Oxidative stress

CLC Number:

R446.1

ZHANG Yan,CHEN Xiaoting,SONG Huizhu,QI Zhigang. Research progress on molecular pathogenesis of obesity-induced insulin resistance[J]. , 2014, 29(7): 774-777.

References

[1] 宋颖,李启富. 不同种族胰岛素抵抗状态比较及相关影响因素 [J]. 中国糖尿病杂志, 2013, 21(1): 91-92.
[2] DeFronzo RA. Insulin resistance,lipotoxicity,type 2 diabetes and atherosclerosis:the missing links. The Claude Bernard Lecture 2009[J]. Diabetologia,2010,53(7):1270-1287.
[3] Regazzetti C,Peraldi P,Grémeaux T,et al. Hypoxia decreases insulin signaling pathways in adipocytes [J]. Diabetes,2009,58(1):95-103.
[4] Byrne CD. Fatty liver:role of inflammation and fatty acid nutrition [J]. Prostaglandins Leukotr Essent Fatty Acids, 2010,82(4-6):265-271.
[5] 王依屹,张珏,鲁传翠. 2型糖尿病患者胰岛素抵抗与血清游离脂肪酸浓度关系[J]. 检验医学, 2012, 27(10): 806-808.
[6] Lennon R,Pons D,Sabin MA,et al. Saturated fatty acids induce insulin resistance in human podocytes:implications for diabetic nephropathy [J]. Nephrol Dial Transplant,2009,24(11):3288-3296.
[7] 白宇娜,郑佳,宋振峰,等. 姜黄素对胰岛素抵抗小鼠脂联素表达的影响 [J]. 上海交通大学学报(医学版),2013,33(2): 136-139.
[8] Bu J, Feng Q, Ran J,et al. Visceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects [J]. Diabetes Res Clin Pract, 2012,96(2):163-169.
[9] Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin [J]. Proc Jpn Acad Ser B Phys Biol Sci,2010,86(2):131-141.
[10] Fernández-Veledo S,Vila-Bedmar R,Nieto-Vazquez I,et al. c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes:reversal by liver X receptor agonists [J]. J Clin Endocrinol Metab,2009,94(9):3583-3593.
[11] Indulekha K,Anjana RM,Surendar J,et al. Association of visceral and subcutaneous fat with glucose intolerance,insulin resistance,adipocytokines and inflammatory markers in Asian Indians (CURES-113) [J]. Clin Biochem,2011,44(4):281-287.
[12] Ozcelik F, Yuksel C, Arslan E, et al. Relationship between visceral adipose tissue and adiponectin, inflammatory markers and thyroid hormones in obese males with hepatosteatosis and insulin resistance [J]. Arch Med Res, 2013, 44(4):273-280.
[13] Lionetti L,Mollica MP,Lombardi A,et al. From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation [J]. Nutr Metab Cardiovas Dis,2009,19(2):146-152.
[14] Schaeffler A,Gross P,Buettner R,et al. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity [J]. Immunology,2009,126(2):233-245.
[15] Huang F, Liu K, Du H, et al. Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner [J]. Biochimie,2012,94(5):1143-1150.
[16] Liu K, Zhao W, Gao X, et al. Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways [J]. Atherosclerosis,2012,223(2):350-358.
[17] Vichaiwong K,Henriksen EJ,Toskulkao C,et al. Attenuation of oxidant-induced muscle insulin resistance and p38 MAPK by exercise training [J]. Free Radic Bio Med,2009,47(5):593-599.
[18] White M,Lepage S,Lavoie J,et al. Effects of combined candesartan and ACE inhibitors on BNP,markers of inflammation and oxidative stress,and glucose regulation in patients with symptomatic heart failure [J]. J Card Fail,2007,13(2):86-94.
[19] He B,Zhao S,Zhang W,et al. Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids [J]. Hepatobiliary Pancreat Dis Int,2010,9(1):49-53.
[20] He B,Zhao S,Zhang W,et al. Salicylate prevents hepatic oxidative stress activation caused by short-term elevation of free fatty acids in vivo [J]. Diabetes Res Clin Pract,2010,89(2):150-156.
[21] Gao D,Nong S,Huang X,et al. The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways [J]. J Biol Chem,2010,285(39):29965-29973.

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