Number and activity of peripheral blood eosinophils in obese people

doi:10.3969/j.issn.1673-8640.2023.09.008

Abstract

Abstract:

Objective To analyze the number and activity of peripheral blood eosinophils in obese people. Methods A total of 41 subjects >40 years old at Guang' anmen Hospital from June to September 2021 were enrolled. According to body mass index（BMI），the subjects were classified into obese group（20 cases，BMI≥30 kg/m²） and control group（21 cases，18.5 kg/m²<BMI<28 kg/m²）. The general information were collected. The expressions of CD62L and CD63 in peripheral blood eosinophils were determined by flow cytometry. The level of serum eosinophil cationic protein（ECP） was determined by enzyme-linked immunosorbent assay（ELISA）. The number and percentage of peripheral blood eosinophils and the expressions of CD62L，CD63 and ECP were compared between the 2 groups. Results The number and percentage of peripheral blood eosinophils and neutrophils and serum ECP levels in obese group were higher than those in control group（P>0.05）. CD62L was lower than that in control group（P<0.05），and CD63 was higher than that in control group（P<0.01）. CD62L was negatively correlated with BMI（r=-0.332，P=0.034）. Conclusions Obesity might be related to the increase of peripheral blood eosinophil activity.

Key words: Eosinophil, Eosinophil cationic protein, Obesity

CLC Number:

R446.11

CHENG Xu, YANG Cunqing, PANG Bo, GU Chun, HOU Xueyun, FEI Jiaxin, WU Min, LI Jun, LIU Guijian. Number and activity of peripheral blood eosinophils in obese people[J]. Laboratory Medicine, 2023, 38(9): 855-859.

Figures/Tables 3

References 28

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组别	例数	性别		年龄/岁	丙氨酸氨基转移酶/（U/L）	天门冬氨酸氨基转移酶/（U/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
组别	例数	男/ [例（%）]	女/ [例（%）]	年龄/岁	丙氨酸氨基转移酶/（U/L）	天门冬氨酸氨基转移酶/（U/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
对照组	21	6（28.6）	15（71.4）	62±6	21.00（13.50，29.00）	21.00（17.50，27.00）	1.30±0.23	3.57±0.79
肥胖组	20	5（25.0）	15（75.0）	64±7	19.50（17.00，29.23）	22.00（18.25，24.83）	1.26±0.23	3.22±0.68
统计值		0.067		0.785	0.052	0.091	0.391	0.887
P值		0.538		0.404	0.958	0.927	0.572	0.142
组别	三酰甘油/ （mmol/L）		血糖/（mmol/L）		中性粒细胞计数/（×10⁹/L）	中性粒细胞百分比/%	嗜酸性粒细胞计数/（×10⁹/L）	嗜酸性粒细胞百分比/%
对照组	1.62（1.15，2.25）		5.33（5.00，6.00）		3.63±0.97	56.30（53.65，61.90）	0.11（0.07，0.17）	1.80（1.40，2.90）
肥胖组	1.85（1.55，2.35）		5.60（5.10，6.88）		3.94±1.24	56.05（52.3，69.00）	0.14（0.08，0.28）	2.25（1.40，3.78）
统计值	1.356		0.863		0.901	0.730	1.032	0.953
P值	0.175		0.388		0.376	0.465	0.302	0.341

组别	例数	性别		年龄/岁	丙氨酸氨基转移酶/（U/L）	天门冬氨酸氨基转移酶/（U/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
组别	例数	男/ [例（%）]	女/ [例（%）]	年龄/岁	丙氨酸氨基转移酶/（U/L）	天门冬氨酸氨基转移酶/（U/L）	高密度脂蛋白胆固醇/（mmol/L）	低密度脂蛋白胆固醇/（mmol/L）
对照组	21	6（28.6）	15（71.4）	62±6	21.00（13.50，29.00）	21.00（17.50，27.00）	1.30±0.23	3.57±0.79
肥胖组	20	5（25.0）	15（75.0）	64±7	19.50（17.00，29.23）	22.00（18.25，24.83）	1.26±0.23	3.22±0.68
统计值		0.067		0.785	0.052	0.091	0.391	0.887
P值		0.538		0.404	0.958	0.927	0.572	0.142
组别	三酰甘油/ （mmol/L）		血糖/（mmol/L）		中性粒细胞计数/（×10⁹/L）	中性粒细胞百分比/%	嗜酸性粒细胞计数/（×10⁹/L）	嗜酸性粒细胞百分比/%
对照组	1.62（1.15，2.25）		5.33（5.00，6.00）		3.63±0.97	56.30（53.65，61.90）	0.11（0.07，0.17）	1.80（1.40，2.90）
肥胖组	1.85（1.55，2.35）		5.60（5.10，6.88）		3.94±1.24	56.05（52.3，69.00）	0.14（0.08，0.28）	2.25（1.40，3.78）
统计值	1.356		0.863		0.901	0.730	1.032	0.953
P值	0.175		0.388		0.376	0.465	0.302	0.341