The analysis of IgE and eosinophil determinations in acute and chronic urticaria children

doi:10.3969/j.issn.1673-8640.2014.11.010

Abstract

Abstract:

Objective　To investigate IgE levels, eosinophil change and their clinical significance in acute and chronic urticaria children. Methods　Respectively by chemiluminescence, enzyme-linked immunofluorescence and volume, conductivity and scattering (VCS) principle, serum total IgE levels, food, mites and plant-specific IgE levels and eosinophil percentages were determined, and the samples were collected from 77 acute and 46 chronic urticaria children. The differences between acute and chronic urticaria children were analyzed comparatively. Results　There was no statistical significance in total IgE levels and positive rates to food, mites and plant-specific IgE levels between acute and chronic urticaria children with other allergic diseases(P>0.05), but there was a significantly higher total IgE level in chronic group than that in acute group in acute and chronic urticaria children without other allergic diseases (P<0.05). Boys had significantly higher serum total IgE levels than girls. The total IgE levels had a trend of increasing with age. There was a higher positive rate to mites-specific IgE than food and plant-specific IgE(P<0.05). The eosinophil percentages of acute and chronic urticaria children had no statistical significance (P>0.05). Conclusions　Eosinophil percentage is not a good index for differential diagnosis in acute and chronic urticaria children. IgE has a certain significance for diagnosing acute and chronic urticaria without other allergic diseases. However, in other cases, serum level of total IgE is not a good index for differential diagnosis in acute and chronic urticaria children. Integrating case history, course of disease and clinical symptom can help with making a correct diagnosis.

Key words: Immunoglobulin, Eosinophil, Urticaria, Child

CLC Number:

R446.62

CAI Defeng, LU Yuanshan, YUAN Yan, YANG Xiaolin, WU Yueping, MA Dongli. The analysis of IgE and eosinophil determinations in acute and chronic urticaria children[J]. , 2014, 29(11): 1120-1123.

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