Roles of serum 25-hydroxyvitamin D and bone mineral density in children with obesity

doi:10.3969/j.issn.1673-8640.2018.08.001

Abstract

Abstract:

Objective To investigate the relations of 25-hydroxyvitamin D [25（OH）D] and bone mineral density with blood lipid,blood glucose and insulin resistance in children with simple obesity.Methods The levels of 25（OH）D,fasting blood glucose（FBG）,fasting insulin（FINS）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C） and uric acid（UA）were determined in 109 children with simple obesity（obesity group） and 104 healthy children（healthy control group）. The homeostasis model assessment for insulin resistance（HOMA-IR） was calculated. The speed of sound（SOS） of left tibial bone was measured by ultrasonography. The obesity group was classified into mild obesity,moderate obesity and severe obesity groups according to body mass index （BMI）. The levels of 25（OH）D and SOS among the 3 groups were compared. The correlation between 25（OH）D and other indicators was evaluated by Pearson linear correlation analysis.Results The UA,TG,TC,LDL-C and FBG in obesity group were higher than those in healthy control group（P<0.05）,while 25（OH）D and SOS were lower（P<0.05）. In obesity group,25（OH）D was negatively correlated to TG（r=-0.279,P<0.05）,while there was no correlation between 25（OH）D and FINS,FBG,HOMA-IR,UA,TC,HDL-C and LDL-C（r=-0.144,-0.027,-0.144,-0.049,-0.106,0.021 and -0.137,P>0.05）. The levels of 25（OH）D and SOS in mild obesity,moderate obesity and severe obesity groups were gradually decreased with the degrees of obesity with statistical significance（P<0.05）.Conclusions The levels of 25（OH）D and SOS are gradually decreased in children with simple obesity with the degrees of obesity. Vitamin D deficiency may be related to obesity.

Key words: 25-Hydroxyvitamin D, Bone mineral density, Children with obesity

CLC Number:

R446.1

LIN Xiangquan, CHEN Hong. Roles of serum 25-hydroxyvitamin D and bone mineral density in children with obesity[J]. Laboratory Medicine, 2018, 33(8): 669-673.

Figures/Tables 2

References 26

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组别	例数	25（OH）D（ng/mL）	SOS（m/s）	UA（μmol/L）	TG（mmol/L）	TC（mmol/L）
肥胖组	109	23.91±6.18	3 744.83±134.16	382.00±98.29	1.01±0.43	4.80±0.88
正常对照组	104	27.09±6.58	3 802.16±140.67	296.39±57.23	0.83±0.64	4.56±0.76
t值		-2.817	-2.792	7.847	2.424	2.144
P值		0.006	0.006	0.000	0.016	0.033
组别	HDL-C（mmol/L）		LDL-C（mmol/L）	FBG（mmol/L）	FINS（μIU/mL）	HOMA-IR
肥胖组	1.61±0.43		2.90±0.64	5.15±0.40	16.27±7.00	3.74±1.69
正常对照组	1.63±0.34		2.71±0.73	4.78±0.51	9.74±2.43	2.07±0.58
t值	-0.371		1.988	5.830	9.013	9.517
P值	0.711		0.048	0.000	0.000	0.000

组别	例数	25（OH）D（ng/mL）	SOS（m/s）	UA（μmol/L）	TG（mmol/L）	TC（mmol/L）
肥胖组	109	23.91±6.18	3 744.83±134.16	382.00±98.29	1.01±0.43	4.80±0.88
正常对照组	104	27.09±6.58	3 802.16±140.67	296.39±57.23	0.83±0.64	4.56±0.76
t值		-2.817	-2.792	7.847	2.424	2.144
P值		0.006	0.006	0.000	0.016	0.033
组别	HDL-C（mmol/L）		LDL-C（mmol/L）	FBG（mmol/L）	FINS（μIU/mL）	HOMA-IR
肥胖组	1.61±0.43		2.90±0.64	5.15±0.40	16.27±7.00	3.74±1.69
正常对照组	1.63±0.34		2.71±0.73	4.78±0.51	9.74±2.43	2.07±0.58
t值	-0.371		1.988	5.830	9.013	9.517
P值	0.711		0.048	0.000	0.000	0.000

组别	例数	25（OH）D（ng/mL）	SOS （m/s）
轻度肥胖组	60	25.22±6.68	3 778.63±131.35
中度肥胖组	34	22.59±5.00	3 708.50±120.08
重度肥胖组	15	21.67±4.88	3 671.50±128.02
F值		3.232	5.049
P值		0.043	0.008

组别	例数	25（OH）D（ng/mL）	SOS （m/s）
轻度肥胖组	60	25.22±6.68	3 778.63±131.35
中度肥胖组	34	22.59±5.00	3 708.50±120.08
重度肥胖组	15	21.67±4.88	3 671.50±128.02
F值		3.232	5.049
P值		0.043	0.008