Abstract:

Objective To investigate the relationship between serum 25-hydroxyvitamin D [25（OH）D],specific immunoglobulin E（IgE） and visual analog scale（VAS） score in children with allergic rhinitis. Methods Serum 25（OH）D and specific IgE level were determined in 38 children with AR（AR group）,38 children without AR（non-AR group） and 40 healthy children（healthy control group）,and VAS was evaluated in all children with AR. Receiver operating characteristic（ROC） curve was used to evaluate the role of 25（OH）D in judging moderate or severe AR. Results The level of 25（OH）D in AR group was lower than those in non-AR group and healthy control group（P<0.05）,and the level of specific IgE in AR group was higher than those in non-AR group and healthy control group（P<0.05）. The level of 25（OH）D in mild group was higher than those in moderate and severe group（P<0.05）,and the level of specific IgE was lower than those in moderate and severe group（P<0.05）. Correlation analysis showed that VAS was negatively correlated with 25（OH）D（r=-0.637,P<0.001）,and it had a positive correlation with specific IgE（r=0.654,P<0.001）. ROC curve analysis showed that the area under the curve of 25（OH）D was 0.862,and the optimal cut-off value was 10.13 ng/mL,with the sensitivity of 81.3% and the specificity of 78.6%. Conclusions The level of 25（OH）D and specific IgE have certain value in the auxiliary diagnosis and judgment of the severity of child AR.

Key words: 25-Hydroxyvitamin D, Specific immunoglobulin E, Allergic rhinitis