Correlation of bone mineral density with bone turnover biochemical markers in postmenopausal women

doi:10.3969/j.issn.1673-8640.2017.05.003

Abstract

Abstract:

Objective To analyze the correlation of bone mineral density with bone turnover biochemical markers in premenopausal and postmenopausal women,and to investigate the levels of bone metabolism biochemical markers of women with decreasing bone mineral density in premenopause and postmenopause. Methodse Bone mineral densities of lumbar spine（L1-L4）and femoral neck were determined by dual energy X-ray. According to bone mineral densities,185 postmenopausal 45-65-year-old women were classified into bone mass normal group（50 cases）,bone mass loss group （35 cases）and osteoporosis group （100 cases）. A total of 45 postmenopausal 51-70-year-old women with decreasing bone mineral density were enrolled as postmenopausal decreasing bone mineral density group. A total of 25 premenopausal 42-50-year-old women with decreasing bone mineral density were enrolled as premenopausal decreasing bone mineral density group. Enzyme-linked immunosorbent assay（ELISA）was used to determine the levels of serum cathepsin K （Cathe K）,bone alkaline phosphatase（B-ALP）and tartrate-resistant acid phosphatase （TRAP）. The levels of osteocalcin,beta-collagen degradation product（β-crosslaps）and type Ⅰ procollagen N-terminal propeptide （PⅠNP）were determined by electrochemiluminescence. Results The levels of serum Cathe K,PⅠNP,β-crosslaps,osteocalcin and TRAP in osteoporosis group were higher than those in bone mass normal group （P<0.05）,which showed negative correlations with the bone mineral density of lumbar spine or femoral neck （P<0.05）,and B-ALP level was slightly lower than that in bone mass normal group without statistical significance （P>0.05）. Serum Cathe K and TRAP levels were lower in postmenopausal decreasing bone mineral density group than those in premenopausal decreasing bone mineral density group（P<0.01）,and serum PⅠNP and osteocalcin levels were higher（P<0.01）. The bone mineral densities of lumbar spine and femoral neck and the levels of β-crosslaps and B-ALP in the premenopausal and postmenopausal groups had no statistical significance（P>0.05）. Conclusions Postmenopausal women with osteoporosis is high turnover type. The levels of serum osteocalcin,β-crosslaps,PⅠNP,B-ALP,TRAP and Cathe K can reflect bone metabolism. Bone mineral density examination combined with bone turnover biochemical markers can be used for the prevention and treatment monitoring of osteoporosis.

Key words: Bone turnover biochemical markers, Osteoporosis, Bone mineral density, Postmenopausal women

CLC Number:

R446.1

WANG Rong, CHEN Guangjie, SHEN Anda, HUANG Keliang, ZHOU Yingliang. Correlation of bone mineral density with bone turnover biochemical markers in postmenopausal women[J]. Laboratory Medicine, 2017, 32(5): 361-366.

Figures/Tables 4

References 25

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组别	例数	股骨颈	腰椎（L1~L4）
骨量减少组	50	0.78±0.06^*	0.83±0.07^*
骨质疏松组	100	0.63±0.12^**	0.66±0.09^**
骨量正常组	50	0.90±0.07	0.94±0.06

组别	例数	股骨颈	腰椎（L1~L4）
骨量减少组	50	0.78±0.06^*	0.83±0.07^*
骨质疏松组	100	0.63±0.12^**	0.66±0.09^**
骨量正常组	50	0.90±0.07	0.94±0.06

组别	例数	Cathe K （ng/L）	PⅠNP （ng/mL）	β-crosslaps （ng/mL）	骨钙素（ng/mL）	B-ALP （pg/mL）	TRAP （pg/L）
骨量减少组	35	23.8±20.4	46.6±6.4	0.6±0.3	12.9±3.8	1 852.3±200.9	2 433.2±474.9
骨质疏松组	100	33.0±22.8^*	79.7±5.9^*	0.9±0.3^*	17.7±5.6^*	1 638.8±430.4	2 727.5±1 297.2^*
骨量正常组	50	24.6±12.6	53.2±4.6	0.6±0.1	11.8±2.9	1 651.2±237.5	2 403.2±408.1

组别	例数	Cathe K （ng/L）	PⅠNP （ng/mL）	β-crosslaps （ng/mL）	骨钙素（ng/mL）	B-ALP （pg/mL）	TRAP （pg/L）
骨量减少组	35	23.8±20.4	46.6±6.4	0.6±0.3	12.9±3.8	1 852.3±200.9	2 433.2±474.9
骨质疏松组	100	33.0±22.8^*	79.7±5.9^*	0.9±0.3^*	17.7±5.6^*	1 638.8±430.4	2 727.5±1 297.2^*
骨量正常组	50	24.6±12.6	53.2±4.6	0.6±0.1	11.8±2.9	1 651.2±237.5	2 403.2±408.1

项目	股骨颈骨密度	腰椎（L1~L4 ）骨密度	Cathe K	PⅠNP	β-crosslaps	骨钙素	B-ALP
腰椎（L1~L4）骨密度
r值	0.759
P值	0.007
Cathe K
r值	-0.098	-0.312
P值	0.664	0.036
PⅠNP
r值	-0.146	-0.383	0.268
P值	0.246	0.028	0.042
β-crosslaps
r值	-0.459	-0.389	0.262	0.945
P值	0.028	0.028	0.048	0.000
骨钙素
r值	-0.069	-0.322	0.364	0.516	0.517
P值	0.334	0.033	0.029	0.016	0.016
B-ALP
r值	-0.128	-0.123	-0.357	0.485	0.509	0.496
P值	0.324	0.483	0.030	0.024	0.017	0.022
TRAP
r值	-0.141	-0.292	0.263	0.481	0.537	0.483	0.520
P值	0.383	0.040	0.048	0.024	0.005	0.024	0.011