Abstract:

Objective To evaluate the correlation between the markers of bone metabolism and bone mineral density in patients with type 2 diabetes mellitus（T2DM）.Methods The bone mineral densities of lumbar spine and hip bone were measured by dual-energy X-ray absorptiometry in 200 elderly patients with T2DM. According to the bone mineral densities,patients were classified into 3 groups,including normal group（75 cases）,osteopenia group（72 cases） and osteoporosis group（53 cases）. The height,weight and body mass index（BMI） for all patients were recorded. The markers of bone metabolism,including total type Ⅰ collagen N-terminal peptide（TPⅠNP）,type Ⅰ collagen carboxyl-terminal peptide（β-CTX）,bone gamma-carboxyglutamic-acid-containing protein（BGP） and 25-hydroxyvitamin D [25（OH）D],were determined. The levels of fasting blood glucose（FBG）,glycated hemoglobin A_1c（HbA_1c）,fasting C peptide,parathyroid hormone（PTH）,serum calcium,24 h urinary protein（UP） were determined by electro-chemiluminescence.Results Compared with normal group,the levels of BMI,fasting C peptide,25（OH）D,BGP and TPⅠNP were decreased（P<0.05）,while the levels of β-CTX,24 h UP,PTH and HbA_1c were increased in osteopenia and osteoporosis groups（P<0.05）. For age,diabetes mellitus duration,FBG and calcium levels,there was no statistical significance among the 3 groups（P>0.05）. Moreover,bone mineral densities were positively correlated with the levels of BGP,TPⅠNP and 25（OH）D （r=0.273,0.269 and 0.223,P<0.01,0.05 and 0.01）. The level of β-CTX showed a negative correlation with bone mineral densities（r= -0.246,P<0.01）. Conclusions The markers of bone metabolism are related to bone mineral density in patients with T2DM,who easily merge with osteopenia,even osteoporosis.

Key words: Bone metabolism markers, 25-Hydroxyvitamin D, Type 2 diabetes mellitus, Bone mineral density