Abstract:

Objective To investigate the correlations of serum adipsin and vitamin D（Vit D） with islet beta cell function and insulin sensitivity in patients with type 2 diabetes mellitus（T2DM）. Methods A total of 60 patients with T2DM and 60 patients with impaired glucose tolerance（IGT） were enrolled,and 60 healthy subjects were enrolled as control group. Serum adipsin,fasting plasma glucose（FPG）,fasting insulin（FINS） and Vit D were determined. The acute insulin response（AIR）,the homeostasis model assessment beta（HOMA-β） and insulin sensitivity index（ISI） were calculated. Multivariate Logistics regression analysis was used to study the influencing factors of serum adipsin and Vit D,and Pearson correlation analysis was used to study the correlations of serum adipsin and Vit D with AIR,HOMA-β and ISI. Results The levels of serum adipsin and Vit D in T2DM group were lower than those in IGT group and control group,while the levels of FPG and FINS were higher than those in IGT group and control group（P<0.05）. Body mass index（BMI）and waist-to-hip ratio had statistical significance among the 3 groups（P<0.05）,and sex and age had no statistical significance（P<0.05）. HOMA-β,ISI and AIR were the risk factors for serum adipsin and Vit D levels（P<0.05）. Serum adipsin and Vit D in T2DM patients were positively correlated with HOMA-β and ISI（P<0.05）,while serum adipsin and Vit D were positively correlated（P<0.05）. Conclusions Serum adipsin and Vit D levels are correlated with islet beta cell function and insulin sensitivity in patients with T2DM.

Key words: Adipsin, Vitamin D, Islet beta cell function, Insulin sensitivity, Type 2 diabetes mellitus