Abstract:

Objective To investigate the changes and clinical significance of liver function and oxidative stress in patients with nonalcoholic fatty liver,and to provide a reference for clinical diagnosis and treatment. Methods A total of 120 patients with nonalcoholic fatty liver were enrolled as study group,and 100 healthy subjects were enrolled as control group. The liver function and oxidative stress were compared between the 2 groups. The correlation of liver function and oxidative stress with nonalcoholic fatty liver was analyzed by Pearson single factor analysis,and the diagnostic value of liver function,oxidative stress and the combined determination in patients with nonalcoholic fatty liver was analyzed by receiver operating characteristic（ROC）curve. Results The levels of alanine aminotransferase（ALT）,aspartate aminotransferase（AST） and gamma-glutamyltransferase（GGT） in study group [（43.69±6.12） U/L,（36.37±5.04） U/L,（48.07±6.41） U/L] were higher than those in control group [（23.36±3.37） U/L,（21.64±3.15） U/L,（20.85±3.08） U/L]（P<0.05）. The levels of glutathione（GSH） and malondialdehyde（MDA） in study group were （321.84±42.75）μmol/L and （6.30±2.02）U/mL,which were higher than those in control group [（270.61±30.37） μmol/L,（2.25±1.40） U/mL]. The levels of catalase（CAT） and total superoxide dismutase（SOD） were （40.72±6.20）U/mL and （80.27±11.78）U/mL,which were lower than those in control group [（53.42±6.91） U/mL,（92.82±12.27） U/mL]（P<0.05）. Pearson correlation analysis showed that liver function,GSH and MDA levels were positively correlated with nonalcoholic fatty liver（r=0.835,0.722 and 0.741,P<0.05）,and CAT and SOD levels were negatively correlated with nonalcoholic fatty liver（r=-0.685 and -0.712,P<0.05）. ROC curve analysis showed that the area under curve（AUC）,sensitivity and specificity of the combined determination were 0.862,86.79% and 93.24%,respectively,which were higher than those of the single determinations of liver function and oxidative stress（0.670,62.03%,81.82%;0.754,77.64%,64.55%）（P<0.05）. Conclusions Nonalcoholic fatty liver patients have severe liver function and oxidative stress damage. The higher the liver function,GSH and MDA levels are,and the lower the CAT and SOD levels are,the greater the risk of nonalcoholic fatty liver is. The combined determination of liver function and oxidative stress can effectively improve the sensitivity and specificity in the diagnosis of nonalcoholic fatty liver,and it is worthy of clinical application.

Key words: Liver function, Oxidative stress, Nonalcoholic fatty liver