Abstract:

Objective To investigate the relationship of soluble vascular adhesion protein-1（sVAP-1）,liver function parameters and serum hepatitis C virus（HCV）RNA loads in chronic hepatitis C patients. Methods The clinical data of 400 chronic hepatitis C patients and 207 healthy subjects were analyzed retrospectively. Real-time fluorescence quantitation polymerase chain reaction （PCR） was used to determine HCV RNA. Double-antibody sandwich enzyme-linked immunosorbent assay （ELISA）was used to determine serum level of sVAP-1,and automatic biochemistry analyzer was used to determine liver function parameters. The results were recorded and analyzed. Results Serum sVAP-1 level in chronic hepatitis C patients was higher than that in healthy subjects （P<0.01）. Serum sVAP-1 level in chronic hepatitis C patients with alanine aminotransferase ≤50 IU/L was lower than that >50 IU/L（P<0.01）. Serum level of sVAP-1 in patients with Child-Pugh grade C was higher than those in grade A and grade B （P<0.05）. Serum sVAP-1 had positive correlations with aspartate aminotransferase and alanine aminotransferase （r=0.832 and 0.749,P<0.01） and a negative correlation with albumin （r=-0.152,P<0.05）. There was no correlation with serum HCV RNA loads （r=0.087,P>0.05）. Conclusions Serum sVAP-1 level in patients with chronic hepatitis C increases,and serum sVAP-1 is positively correlated with hepatocellular inflammatory injury in patients with chronic hepatitis C.

Key words: Soluble vascular adhesion protein-1, Liver function parameter, RNA, Hepatitis C virus, Chronic hepatitis C