Laboratory Medicine ›› 2023, Vol. 38 ›› Issue (6): 594-598.DOI: 10.3969/j.issn.1673-8640.2023.06.017
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ZHANG Min, WANG Binyu, CHI Weiqun, LIU Yu()
Received:
2022-04-07
Revised:
2023-02-08
Online:
2023-06-30
Published:
2023-08-22
CLC Number:
ZHANG Min, WANG Binyu, CHI Weiqun, LIU Yu. Research progress of exosomal non-coding RNA as biomarkers for disease diagnosis[J]. Laboratory Medicine, 2023, 38(6): 594-598.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2023.06.017
疾病类型 | 标本类型 | 外泌体ncRNA及其表达变化 | AUC | 参考文献 |
---|---|---|---|---|
呼吸系统疾病 | ||||
过敏性哮喘 | 肺泡灌洗液 | miR-223↑ miR-142a↑ | [ | |
非小细胞肺癌 | 血清 | lncRNA GAS5↓ | 0.822 | [ |
消化系统疾病 | ||||
酒精性肝炎 | 血浆 | miR-192↑ miR-30a↑ | 0.950 0.580 | [ |
胃癌 | 血清 | lncRNA GC1↑ | 0.902 | [ |
结直肠癌 | 血清 | lncRNA CRNDE-h↑ | 0.892 | [ |
循环系统疾病 | ||||
不稳定型心绞痛 | 血清 | miR-126↑ miR-21↓ | 0.782 0.824 | [ |
急性心肌梗死 | 血清 | miR-126↑ miR-21↓ lncRNA ENST00000556899.1↑ lncRNA ENST00000575985.1↑ | 0.849 0.842 0.661 0.751 | [ [ |
心力衰竭 | 血清 | miR-192-5p↑ | 0.844 | [ |
泌尿系统疾病 | ||||
IgA肾病 | 血浆 | lncRNA G21551↓ | [ | |
特发性膜性肾病 | 血清、尿液 | 89种circRNA表达发生改变,如circ-MUC3A↑ | [ | |
膀胱癌 | 尿液 | lncRNA MALAT1↑ lncRNA PCAT-1↑ lncRNA SPRY4-IT1↑ | 0.785 0.810 0.799 | [ |
神经系统疾病 | ||||
帕金森病 | 脑脊液 | miR-1↓ miR-19b-3p↓ miR-153↑ miR-409-3p↑ miR-10a-5p↑ | 0.920 0.705 0.780 0.970 0.900 | [ |
阿尔茨海默病 | 血清、脑脊液 | miR-193b↑ | [ | |
内分泌系统疾病 | ||||
1型糖尿病 | 血浆 | miR-16-5p↓ miR-574-5p↓ miR-302d-3p↓ | [ | |
甲状腺结节 | 血浆 | miR-16-2-3p↓ miR-223-5p↓ miR-34c-5p↓ miR-182-5p↓ miR-223-3p↓ miR-146b-5p↓ | 0.940 0.950 0.880 0.910 0.860 0.810 | [ |
血液系统疾病 | ||||
慢性淋巴细胞白血病 | 血浆 | miR-29a↑ miR-29b↑ miR-29c↑ miR-150↑ miR-155↑ | [ | |
急性髓系白血病 | 血清 | circ-0004136↑ | [ | |
弥漫性大B细胞淋巴瘤 | 血清 | miR-99a-5p↑ miR-125b-5p↑ | [ | |
多发性骨髓瘤 | 血清 | circ-ATP10A↑ | [ |
疾病类型 | 标本类型 | 外泌体ncRNA及其表达变化 | AUC | 参考文献 |
---|---|---|---|---|
呼吸系统疾病 | ||||
过敏性哮喘 | 肺泡灌洗液 | miR-223↑ miR-142a↑ | [ | |
非小细胞肺癌 | 血清 | lncRNA GAS5↓ | 0.822 | [ |
消化系统疾病 | ||||
酒精性肝炎 | 血浆 | miR-192↑ miR-30a↑ | 0.950 0.580 | [ |
胃癌 | 血清 | lncRNA GC1↑ | 0.902 | [ |
结直肠癌 | 血清 | lncRNA CRNDE-h↑ | 0.892 | [ |
循环系统疾病 | ||||
不稳定型心绞痛 | 血清 | miR-126↑ miR-21↓ | 0.782 0.824 | [ |
急性心肌梗死 | 血清 | miR-126↑ miR-21↓ lncRNA ENST00000556899.1↑ lncRNA ENST00000575985.1↑ | 0.849 0.842 0.661 0.751 | [ [ |
心力衰竭 | 血清 | miR-192-5p↑ | 0.844 | [ |
泌尿系统疾病 | ||||
IgA肾病 | 血浆 | lncRNA G21551↓ | [ | |
特发性膜性肾病 | 血清、尿液 | 89种circRNA表达发生改变,如circ-MUC3A↑ | [ | |
膀胱癌 | 尿液 | lncRNA MALAT1↑ lncRNA PCAT-1↑ lncRNA SPRY4-IT1↑ | 0.785 0.810 0.799 | [ |
神经系统疾病 | ||||
帕金森病 | 脑脊液 | miR-1↓ miR-19b-3p↓ miR-153↑ miR-409-3p↑ miR-10a-5p↑ | 0.920 0.705 0.780 0.970 0.900 | [ |
阿尔茨海默病 | 血清、脑脊液 | miR-193b↑ | [ | |
内分泌系统疾病 | ||||
1型糖尿病 | 血浆 | miR-16-5p↓ miR-574-5p↓ miR-302d-3p↓ | [ | |
甲状腺结节 | 血浆 | miR-16-2-3p↓ miR-223-5p↓ miR-34c-5p↓ miR-182-5p↓ miR-223-3p↓ miR-146b-5p↓ | 0.940 0.950 0.880 0.910 0.860 0.810 | [ |
血液系统疾病 | ||||
慢性淋巴细胞白血病 | 血浆 | miR-29a↑ miR-29b↑ miR-29c↑ miR-150↑ miR-155↑ | [ | |
急性髓系白血病 | 血清 | circ-0004136↑ | [ | |
弥漫性大B细胞淋巴瘤 | 血清 | miR-99a-5p↑ miR-125b-5p↑ | [ | |
多发性骨髓瘤 | 血清 | circ-ATP10A↑ | [ |
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