The clinical application significance of serum total bile acid detection in intrahepatic cholestasis of pregnancy

doi:10.3969/j.issn.1673-8640.2015.05.031

Abstract

Abstract:

Intrahepatic cholestasis of pregnancy(ICP) can increase the risk of adverse pregnancy outcome, and can seriously affect the prognosis of perinatal infants, and it is one of the main perinatal mortality factors. ICP should be early diagnosed and aggressively treated to reduce perinatal morbidity and mortality. Serum total bile acid(sTBA) is a sensitive index for the early diagnosis and treatment of ICP. This paper reviews the relationship of sTBA with ICP and sTBA with liver function indices, the application significance for ICP, the influence of sTBA on fetus and the pathogenesis of ICP, and reviews the role of sTBA in ICP and its clinical application significance.

Key words: Total bile acid, Intrahepatic cholestasis of pregnancy, Liver function, Index, Pathogenesis

CLC Number:

R446.1

LIU Jintao. The clinical application significance of serum total bile acid detection in intrahepatic cholestasis of pregnancy[J]. Laboratory Medicine, 2015, 30(5): 541-544.

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