Abstract:

Objctive To investigate the correlation of laboratory index and clinical classification in corona virus disease 2019（COVID-19） patients. Methods A total of 342 patients with COVID-19 in Ezhou Central Hospital from January 23,2020 to February 12,2020 were enrolled. There were 196 cases of general group,97 cases of severe group and 49 cases of critical group. Their age,sex,basic diseases,co-infection and blood indexes were compared. Receiver operating characteristic（ROC） curve was used to evaluate the roles of blood indexes in the diagnosis of COVID-19. Results The age and prevalence of basic diseases among the 3 groups had statistical significance（P<0.05）. The proportion of males in critical group was higher than that of females（P<0.05）. The infection rate of co-infection with other respiratory pathogens had statistical significance among the 3 groups（P<0.05）. The infection rates of Mycoplasma pneumoniae and influenza B virus were the highest. In severe group,lymphocyte percentage（LYMPH%）,total protein（TP） and albumin（Alb） were lower than those in general group（P<0.05）,while D-dimer（DD）,fibrinogen（Fg）,erythrocyte sedimentation rate（ESR） and C-reactive protein（CRP） were higher（P<0.05）. In critical group,LYMPH%,TP and Alb were lower than those in severe group（P<0.05）,while white blood cell（WBC） count,DD and procalcitonin（PCT） were higher（P<0.05）. According to ROC curve analysis,ESR,Alb and LYMPH% were the most valuable blood indexes to distinguish general and severe groups,and PCT,LYMPH% and Alb were the most valuable blood indexes to distinguish severe and critical groups. Conclusions ESR,Alb,LYMPH% and PCT determinations are helpful to diagnose the conditions.

Key words: Corona virus disease 2019, Blood index, Clinical classification, Ezhou city