Abstract:

Objective To investigate the correlation between urinary protein and disease progression in patients with corona virus disease 2019（COVID-19）. Methods The fresh urine samples from 268 COVID-19 patients（246 cases of light/common type and 22 cases of severe/critical type） within 3 d of admission and 155 discharged patients were collected. Dry chemical analysis was used for routine urine test. Totally,125 suspected patients without severe acute respiratory syndrome coronavirus 2（SARS-CoV-2）infection were enrolled as control group. Results The positive rates of urinary protein in severe/critical type group and light/common type group were higher than that in control group at admission （P<0.05）. The positive rate of urinary protein in severe/critical type group was higher than that in light/common type group（P<0.000 1）,and there was no statistical significance for the positive rate between the 2 groups at dismission（P>0.05）. There were 23.53%（20/85） patients in 20-39 years old group with positive urinary protein at admission and negative at dismission. There were 38.20%（34/89）patients in 40-59 years old group with positive urinary protein at admission and 5.26% patients with still positive urinary protein at dismission. Creatinine and urea nitrogen in severe/critical type group were higher than those in light/common type group（P<0.000 1）. Conclusions Urinary protein has an indicative effect on the progress of COVID-19.

Key words: Urinary protein, Severe acute respiratory syndrome coronavirus 2, Corona virus disease 2019