Investigation on the correlation of serum ox-LDL level with ultrasound image for nonalcoholic fatty liver disease

doi:10.3969/j.issn.1673-8640.2014.02.007

Abstract

Abstract:

Objective To investigate the correlation of serum oxidized-low density lipoprotein (ox-LDL) with metabolism parameters in different graded nonalcoholic fatty liver disease(NAFLD) patients. Methods Enzyme-linked immunosorbert assay (ELISA) was used to determine the levels of serum ox-LDL of 79 NAFLD patients and 23 healthy controls, and the liver functions, metabolism parameters and serum homocysteine (Hcy) were determined simultaneously. By ultrasound image as the diagnostic standard, NAFLD patients were classified into mild (40 cases), moderate (25 cases) and severe (14 cases) fatty liver groups. The correlation of ox-LDL with other parameters and fatty liver infiltration grade was analyzed. Results Alanine aminotransferase, gamma-glutamyltransferase, triglyceride, total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, apolipoprotein E, Hcy, uric acid, fasting blood glucose, fibronectin and ox-LDL were significantly higher in NAFLD group than in healthy control group(P<0.05). Serum ox-LDL levels in mild fatty liver group were significantly lower than those in moderate fatty liver group and severe fatty liver group(P<0.05). Serum ox-LDL was positively correlated with Hcy, uric acid and total bile acid levels [correlation coefficients (r)=0.375, 0.369 and 0.395; P=0.007, 0.013 and 0.029], and was positively correlated with fatty liver infiltration grade (r＝0.410, P＝0.011). Conclusions The serum ox-LDL level in NAFLD patients increases with the increasing of fatty liver infiltration grade, and ox-LDL is an important factor in liver function impairment and fatty liver disease progression.

Key words: Oxidized-low density lipoprotein, Fatty Liver infiltration grade, Homocysteine, Nonalcoholic fatty liver disease

CLC Number:

R446.1

HU Kesheng, MA Yanhua, LIU Lianhong, LI Wei, LUO Jianxiang. Investigation on the correlation of serum ox-LDL level with ultrasound image for nonalcoholic fatty liver disease[J]. , 2014, 29(2): 118-121.

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