Abstract:

Objective To study the role of the combined determination of interleukin（IL）-6,IL-8,IL-10,tumor necrosis factor-alpha（TNF-α）,homocysteine（Hcy）,high-sensitivity C-reactive protein（hs-CRP）,D-dimer（DD） and lipoprotein（a）[Lp（a）] in patients with acute cerebral infarction（ACI） in Qinghai. Methods A total of 300 patients with ACI were enrolled as ACI group,and 78 healthy subjects were enrolled as healthy control group. The levels of IL-6,IL-8,IL-10,TNF-α,Hcy,hs-CRP,DD and Lp（a） were determined. The relationship between the changes of above-mentioned indexes and cerebral infarction area was analyzed. Result The levels of IL-6,IL-8,IL-10,TNF-α,Hcy,hs-CRP,DD and Lp（a）in ACI group before treatment were higher than those in healthy control group（P<0.05）. Compared with those before treatment, all the indexes in ACI group were decreased after treatment（P<0.05）, and showed a downward trend with the extension of treatment time. The levels of IL-6,IL-8,IL-10,TNF-α,Hcy,hs-CRP,DD and Lp（a） with different cerebral infarction areas were higher than those in healthy control group（P<0.05）. All the indexes of large infarction area group were higher than those of middle infarction area group and small infarction area group（P<0.05）, and those of middle infarction area group were higher than those of small infarction area group（P<0.05）. Receiver operating characteristic（ROC） curve analysis showed that the areas under curves of IL-6,IL-8,IL-10,TNF-α,Hcy,hs-CRP,DD and Lp（a） for the diagnosis of ACI were 0.874,0.808,0.860,0.731,0.710, 0.813,0.658 and 0.705,respectively. Logistic regression analysis showed that the combined detection prediction probability was >0.49,the area under curve was 0.904,the opitmal cut-off value was 0.51,and the sensitivity and specificity were 86.4% and 85.6%,respectively. Conclusions The combined detection of IL-6,IL-8,IL-10,TNF-α,Hcy,hs-CRP,DD and Lp（a）is of significance for the judgment and efficacy evaluation of ACI in Qinghai.

Key words: Interleukin, Tumor necrosis factor-alpha, Homocysteine, High-sensitivity C-reactive protein, D-dimer, Lipoprotein（a）, Acute cerebral infarction, Qinghai area