Laboratory Medicine ›› 2023, Vol. 38 ›› Issue (4): 342-346.DOI: 10.3969/j.issn.1673-8640.2023.04.008
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YANG Zhongxin, LI Xiaoyu(), CHEN Tao, CAO Wenjun
Received:
2021-07-08
Revised:
2022-05-07
Online:
2023-04-28
Published:
2023-06-21
CLC Number:
YANG Zhongxin, LI Xiaoyu, CHEN Tao, CAO Wenjun. Roles of IL-8 and MMP-2 in the prognosis of non-small cell lung cancer patients after thoracoscopic segmentectomy[J]. Laboratory Medicine, 2023, 38(4): 342-346.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2023.04.008
组别 | 例数 | 年龄/岁 | 性别 | 神经侵犯 | 肿瘤分期 | 血管侵袭 | ||||
---|---|---|---|---|---|---|---|---|---|---|
男/例 | 女/例 | 有/例 | 无/例 | Ⅰ期/例 | Ⅱ期/例 | 有/例 | 无/例 | |||
复发组 | 37 | 64.4±7.3 | 20 | 17 | 9 | 28 | 16 | 21 | 9 | 28 |
未复发组 | 64 | 64.9±6.8 | 35 | 29 | 20 | 44 | 30 | 34 | 19 | 45 |
统计值 | 0.347 | 0.004 | 0.549 | 0.125 | 0.337 | |||||
P值 | 0.731 | 0.951 | 0.459 | 0.724 | 0.562 | |||||
组别 | 吸烟史 | 肺癌病理类型 | 体重质量/ (kg/m2) | 肿瘤大小/cm | 手术时间/ min | 术中出血量/mL | ||||
有/例 | 无/例 | 鳞癌/例 | 腺癌/例 | |||||||
复发组 | 23 | 14 | 15 | 22 | 23.08±2.29 | 3.3±1.2 | 177.24±24.56 | 113.78±24.65 | ||
未复发组 | 34 | 30 | 28 | 36 | 23.17±2.34 | 3.5±1.1 | 172.09±31.36 | 110.44±25.17 | ||
统计值 | 0.779 | 0.099 | 0.188 | 0.851 | 0.858 | 0.798 | ||||
P值 | 0.376 | 0.753 | 0.852 | 0.397 | 0.393 | 0.427 |
组别 | 例数 | 年龄/岁 | 性别 | 神经侵犯 | 肿瘤分期 | 血管侵袭 | ||||
---|---|---|---|---|---|---|---|---|---|---|
男/例 | 女/例 | 有/例 | 无/例 | Ⅰ期/例 | Ⅱ期/例 | 有/例 | 无/例 | |||
复发组 | 37 | 64.4±7.3 | 20 | 17 | 9 | 28 | 16 | 21 | 9 | 28 |
未复发组 | 64 | 64.9±6.8 | 35 | 29 | 20 | 44 | 30 | 34 | 19 | 45 |
统计值 | 0.347 | 0.004 | 0.549 | 0.125 | 0.337 | |||||
P值 | 0.731 | 0.951 | 0.459 | 0.724 | 0.562 | |||||
组别 | 吸烟史 | 肺癌病理类型 | 体重质量/ (kg/m2) | 肿瘤大小/cm | 手术时间/ min | 术中出血量/mL | ||||
有/例 | 无/例 | 鳞癌/例 | 腺癌/例 | |||||||
复发组 | 23 | 14 | 15 | 22 | 23.08±2.29 | 3.3±1.2 | 177.24±24.56 | 113.78±24.65 | ||
未复发组 | 34 | 30 | 28 | 36 | 23.17±2.34 | 3.5±1.1 | 172.09±31.36 | 110.44±25.17 | ||
统计值 | 0.779 | 0.099 | 0.188 | 0.851 | 0.858 | 0.798 | ||||
P值 | 0.376 | 0.753 | 0.852 | 0.397 | 0.393 | 0.427 |
组别 | 例数 | IL-8/(ng/L) | MMP-2/(ng/mL) |
---|---|---|---|
复发组 | 37 | 94.49±8.16 | 523.62±47.73 |
未复发组 | 64 | 83.48±7.51 | 451.41±42.04 |
t值 | 6.874 | 7.911 | |
P值 | <0.001 | <0.001 |
组别 | 例数 | IL-8/(ng/L) | MMP-2/(ng/mL) |
---|---|---|---|
复发组 | 37 | 94.49±8.16 | 523.62±47.73 |
未复发组 | 64 | 83.48±7.51 | 451.41±42.04 |
t值 | 6.874 | 7.911 | |
P值 | <0.001 | <0.001 |
项目 | β值 | 标准误 | Wald值 | OR值(95%CI) | P值 |
---|---|---|---|---|---|
IL-8(≥87.52 ng/L) | 3.334 | 0.784 | 24.983 | 24.50(18.94~37.23) | <0.001 |
MMP-2(≥477.86 ng/mL) | 3.187 | 0.772 | 22.769 | 23.56(18.01~38.29) | <0.001 |
项目 | β值 | 标准误 | Wald值 | OR值(95%CI) | P值 |
---|---|---|---|---|---|
IL-8(≥87.52 ng/L) | 3.334 | 0.784 | 24.983 | 24.50(18.94~37.23) | <0.001 |
MMP-2(≥477.86 ng/mL) | 3.187 | 0.772 | 22.769 | 23.56(18.01~38.29) | <0.001 |
项目 | AUC(95%CI) | 最佳临界值 | 敏感性/% | 特异性/% | P值 |
---|---|---|---|---|---|
IL-8 | 0.834(0.749~0.919) | 84.62 ng/L | 89.2 | 75.0 | <0.001 |
MMP-2 | 0.858(0.776~0.940) | 471.50 ng/mL | 89.2 | 76.6 | <0.001 |
项目 | AUC(95%CI) | 最佳临界值 | 敏感性/% | 特异性/% | P值 |
---|---|---|---|---|---|
IL-8 | 0.834(0.749~0.919) | 84.62 ng/L | 89.2 | 75.0 | <0.001 |
MMP-2 | 0.858(0.776~0.940) | 471.50 ng/mL | 89.2 | 76.6 | <0.001 |
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