Abstract:

Objective To evaluate the role of cerebrospinal fluid clinical characteristic for non-small cell lung cancer（NSCLC） patients with leptomeningeal metastasis（LM）.Methods A total of 31 patients with NSCLC LM and 30 patients with primary central nervous system lymphoma（PCNSL） were enrolled. Their imaging characteristics were compared,and serum levels of alpha-fetoprotein（AFP）,carcinoembryonic antigen（CEA）,carbohydrate antigen（CA） 15-3 and CA19-9 were determined by chemiluminescence. The cerebrospinal fluid glucose,total protein and chloride level were determined by hexokinase kinase,bromcresol green/biuret and ion selective electrode methods,respectively. The levels of interleukin （IL）-6 and IL-10 in cerebrospinal fluid were determined by enzyme-linked immunosorbent assay. The determination rates of cerebrospinal fluid tumor cells according to cytology between the 2 groups were compared.Results There was no statistical significance in sex,age and imaging between NSCLC LM and PCNSL groups（P>0.05）. Serum levels of AFP,CEA and CA15-3 in NSCLC LM group were higher than those in PCNSL group（P<0.05）,and CA19-9 had no statistical significance between the 2 groups（P>0.05）. There was no statistical significance in cerebrospinal fluid pressure,nucleated cell count,chloride level and IL-6 between the 2 groups（P>0.05）,while cerebrospinal fluid glucose and IL-10 levels and IL-6/IL-10 ratio in NSCLC LM group had statistical significance compared with PCNSL group（P<0.05）.Conclusions The diagnosis of NSCLC LM should be integrated with clinical characteristics,imaging findings,serum tumor markers' levels and cerebrospinal fluid IL-6 level and IL-6/IL-10 ratio,which could improve the diagnosis of NSCLC LM.

Key words: Non-small cell lung cancer, Leptomeningeal metastasis, Cerebrospinal fluid