Abstract:

Objective To observe the changes of inflammatory factors [C-reactive protein（CRP）,immunoglobulin G（IgG）,neutrophil/lymphocyte ratio（NLR）],cholinesterase（CHE） and homocysteine（Hcy） in peripheral blood of patients with Alzheimer's disease（AD）. Methods A total of 35 AD patients（AD group） and 35 patients with mild cognitive impairment（MCI）（MCI group,disease control group）were enrolled,and 35 healthy subjects were enrolled as healthy control group. CRP and IgG were determined by immunoturbidimetry,the determination of CHE was performed by thio-acetylcholine method,and the determination of Hcy was performed by circulatory enzyme method. The absolute values of neutrophils and lymphocytes were determined by flow cytometry,and the NLR was calculated. Results Hcy and CRP in MCI group were higher than those in healthy control group（P<0.05）,and CHE decreased（P<0.05）. There was no statistical significance of IgG and NLR（P>0.05）. IgG,Hcy,CRP and NLR increased in AD group（P<0.05）,and CHE decreased（P<0.05）. Compared with MCI group,IgG,Hcy and NLR increased in AD group（P<0.05）,and CHE decreased（P<0.05）. There was no statistical significance in CRP（P>0.05）. Hcy and NLR were negatively correlated（r=-0.344,P=0.043）. There was no correlation among the other indicators in AD group（P>0.05）. Conclusions CRP,IgG,CHE,Hcy,NLR may be of value in the diagnosis of AD and differential diagnosis of MCI.

Key words: C-reactive protein, Neutrophil/lymphocyte ratio, Immunoglobulin G, Cholinesterase, Homocysteine, Alzheimer's disease