Arteriosclerotic cardiovascular disease risk markers research progress

doi:10.3969/j.issn.1673-8640.2021.04.021

Abstract

Abstract:

The incidence of cardiovascular diseases is high,the rate of disability is high,and the mortality is high. At present,cardiovascular diseases have become one of the major diseases that seriously endanger human health. Arteriosclerotic cardiovascular disease（ASCVD）risk markers have emerged one after another,and some have become potential targets for intervention. It is helpful for accurate clinical evaluation of patients,which can improve the prevention and treatment of cardiovascular diseases. This review focuses on lipid,hormone,inflammation and nutrition-related ASCVD risk markers.

Key words: Arteriosclerotic cardiovascular disease, Lipoprotein, Hormone, High-sensitivity C-reactive protein, Homocysteine, Omega-3 polyunsaturated fatty acid

CLC Number:

R446.1

WANG Qian, ZHU Shiyao, LU Di, ZHU Kun, WU Jiong, QUAN Jiali. Arteriosclerotic cardiovascular disease risk markers research progress[J]. Laboratory Medicine, 2021, 36(4): 447-452.

Figures/Tables 1

References 56

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标志物	HR值	干预靶点
Lp（a）	1.50~1.60^[9,10]	PCSK9抑制剂、apo（a）单抗药物^[11]
Lp-PLA2	1.55~1.62^[14]	Lp-PLA2抑制剂,但Ⅲ期临床试验失败^[15]
雌激素	0.61~0.74^[20]	激素替代疗法,雌激素受体调节剂^[22]
DHEA、DHEAS	1.61^[25]	补充DHEA和DHEAS^[26]
hs-CRP	1.08~4.3^[27,28]	IL-1β单克隆抗体^[30]
IL-6	1.25^[37]	托珠单抗^[38]
Hcy	1.79^[36]	补充B族维生素^[37]
ω-3 PUFA指数	0.85^[41]	补充EPA和DHA^[48]
维生素D	0.43^[53]	补充维生素D^[54]

标志物	HR值	干预靶点
Lp（a）	1.50~1.60^[9,10]	PCSK9抑制剂、apo（a）单抗药物^[11]
Lp-PLA2	1.55~1.62^[14]	Lp-PLA2抑制剂,但Ⅲ期临床试验失败^[15]
雌激素	0.61~0.74^[20]	激素替代疗法,雌激素受体调节剂^[22]
DHEA、DHEAS	1.61^[25]	补充DHEA和DHEAS^[26]
hs-CRP	1.08~4.3^[27,28]	IL-1β单克隆抗体^[30]
IL-6	1.25^[37]	托珠单抗^[38]
Hcy	1.79^[36]	补充B族维生素^[37]
ω-3 PUFA指数	0.85^[41]	补充EPA和DHA^[48]
维生素D	0.43^[53]	补充维生素D^[54]