Abstract:

Objective To investigate the consistency between the determination of low-density lipoprotein particles（LDL-P） by vertical auto profile（VAP） and the determination of low-density lipoprotein cholesterol（LDL-C） by biochemical homogeneity. Methods A total of 417 patients with coronary atherosclerotic heart disease and 154 healthy subjects were enrolled to determine LDL-P by VAP and LDL-C level by biochemical homogeneity. The 3.37 mmol/L and 1 000 nmol/L were used as the upper limits of the reference intervals for LDL-C and LDL-P，respectively. The samples with consistent LDL-C and LDL-P results were included in group A and classified into group A1（both LDL-C and LDL-P results were normal） and group A2（both LDL-C and LDL-P results were elevated） according to the determination results. The samples with inconsistent LDL-C and LDL-P results were classified into group B，and they were classified into B1（LDL-C normal，LDL-P elevated） and B2（LDL-C elevated，LDL-P normal）. Pearson correlation analysis was used to assess the correlation between the indicators. Results The results of Pearson correlation analysis showed that LDL-C and LDL-P were positively correlated（r=0.666，P=0.000）. There were 181 cases（31.70%） in group A，including 95 cases（16.64%） in group A1 and 86 cases（15.06%） in group A2. There were 390 cases（68.30%） in group B，including 373 cases（65.32%） in group B1 and 17 cases（2.98%） in group B2. Conclusions The inconsistency between LDL-C and LDL-P is mainly present in patients with high LDL-P，suggesting that LDL-P should be clinically concerned to prevent missed determination in subjects with normal LDL-C levels.

Key words: Low-density lipoprotein particle, Low-density lipoprotein cholesterol, Vertical auto profile, Consistency