Abstract:

Objective To know the comparability and consistency of the complete blood cell count（CBC） results of different hematology analyzers in three regions of the Yangtze River Delta,China,and to provide a reference for mutual recognition of CBC results in relevant regions. Methods Totally,2 batches of weakly fixed fresh whole blood samples were transported to 25 clinical laboratories in Qingpu District（Shanghai）,Wujiang District（Jiangsu） and Jiashan District（Zhejiang）. The results of different items were analyzed,and the differences in results between different hematology analyzers were analyzed statistically. Results a For the 2 batches of investigation products,the means and ranges of 5 items were white blood cell（WBC） count 4.04×10⁹/L,0.30×10⁹/L and 8.47×10⁹/L,1.41×10⁹/L,red blood cell（RBC） count 4.11×10¹²/L,0.21×10¹²/L and 5.50×10¹²/L,0.31×10¹²/L,hemoglobin（Hb）128.42 g/L,6.80 g/L and 166.61 g/L,7.20 g/L,hematocrit（HCT）41.97%,9.72% and 52.67%,10.64%,platelet（PLT） count 170.34×10⁹/L,20.40×10⁹/L and 269.82×10⁹/L,32.00×10⁹/L,respectively. The consistency of RBC count and Hb items in the 25 laboratories was better than the others. There was no statistical significance in the CBC results of clinical laboratories in Sysmex system（18 laboratories） and Mindray system（4 laboratories）（P>0.05）,which showed a good consistency. There was statistical significance in the HCT and PLT count between Horiba system（3 laboratories） and others（P<0.05）. Conclusions The CBC results of clinical laboratories in the three regions of Qingpu,Wujiang and Jiashan tend to be comparable and consistent totally. However,there were still differences in some results of different hematology analyzers. It was recommended to use the same hematology system to facilitate mutual recognition of CBC test results in the three regions.

Key words: Complete blood cell count, Hematology analyzer, Consistency, Comparability, Three regions of the Yangtze River Delta