Abstract:

Objective To investigate the roles of plasma thrombin-activatable fibrinolysis inhibitor（TAFI） and serum homocysteine（Hcy） levels in the diagnosis of acute cerebral infarction（ACI）. Methods The levels of TAFI and Hcy in 100 patients with ACI（ACI group） and 100 healthy subjects（healthy control group） were determined. Receiver operating characteristic （ROC） curve was used to evaluate the roles of TAFI and Hcy in the diagnosis of ACI. Pearson correlation analysis was used to evaluate the correlation between TAFI and Hcy. Results Compared with healthy control group,the level of TAFI in ACI group was decreased（P<0.05）,and the level of Hcy in ACI group was increased（P<0.05）. The positive rates of TAFI and Hcy in ACI group were 59% and 65%,respectively,which were higher than those in healthy control group（1% and 5%）（P<0.05）. ROC curve analysis showed that areas under curves （AUC） of TAFI,Hcy single and combined determinations were 0.907,0.828 and 0.949,respectively. The optimal cut-off values were 22.22 μg/mL,14.95 μmol/L and 0.507,respectively. The sensitivities were 78.3%,65.2% and 88.0%,and the specificities were 95.0%,100.0% and 97.0%,respectively. Pearson correlation analysis showed that there was no correlation between TAFI and Hcy in ACI group（r=-0.075,P>0.05）. Conclusions TAFI and Hcy play roles in the diagnosis of ACI.

Key words: Thrombin-activatable fibrinolysis inhibitor, Homocysteine, Acute cerebral infarction