Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome

doi:10.3969/j.issn.1673-8640.2014.02.008

Abstract

Abstract:

Objective To investigate the relationship between the level change of serum retinol binding protein 4(RBP4) and oxidized-low density lipoprotein(ox-LDL) in children with nephrotic syndrome(NS). Methods The levels of serum RBP4 in 118 children with NS(NS group) and 45 healthy children(healthy control group) were determined respectively, the levels of ox-LDL, albumin (Alb), blood lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non HDL-C] andrenal function parameters [urea and creatinine (Cr)] were determined simultaneously, and the results were analyzed statistically. Results The levels of serum RBP4 in NS group [(55.88±27.36)mg/L] were significantly higher than those in healthy control group [(30.61±8.68) mg/L] (P<0.01). The levels of serum RBP4 were positively correlated with ox-LDL, TC, TG, LDL-C, non HDL-C and urea [correlation coefficient (r)=0.30, 0.35, 0.25, 0.29, 0.32 and 0.26, P<0.01].Multiple linear regression analysis found that the changes of TC(β=0.62, P<0.01), urea(β=0.26, P<0.01) and ox-LDL(β=0.20, P<0.05) influenced the 48.4％ of the change of RBP4. In addition, RBP4 was one of factors for the levels of ox-LDL in children with NS. Conclusions The levels of serum RBP4 in children with NS increase significantly, which are associated with the increase of ox-LDL, promoting the occurrence and development of NS.

Key words: Retinol binding protein 4, Oxidized-low density lipoprotein, Lipid metabolism, Child nephrotic syndrome

CLC Number:

R446.1

NIU Dongmei, HONG Jun, WU Jia, SONG Jiaxi, YU Ruijie, YUAN Yunlong, WANG Junjun.. Research on relationship between the levels of serum retinol binding protein 4 and oxidized-low density lipoprotein in children with nephrotic syndrome[J]. , 2014, 29(2): 122-129.

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