Abstract:

Objective To investigate the correlations of mean platelet volume（MPV）,D-dimer（DD） and fibrinogen degradation product（FDP） with cerebral infarction（CI）,its infarct volume and the National Institute of Health stroke scale（NIHSS） score. Methods From January 2016 to December 2018,303 CI patients from the North Campus of Ruijin Hospital of Shanghai Jiao Tong University School of Medicine were enrolled as CI group,and 70 healthy subjects were enrolled as control group. MPV,DD and FDP levels were determined. The difference of MPV,DD and FPD with different infarct volumes was analyzed. The correlations of MPV,DD and FPD with NIHSS score were analyzed. The correlations of MPV with DD and FPD were evaluated. Results Compared with control group,MPV,DD and FDP levels of CI group were increased（P<0.05）. In CI group,MPV was positively correlated with DD and FDP（P<0.05）. The MPV,DD and FDP levels in patients with small infarct size,medium infarct size and large infarct size were increased in turn（P<0.05）. The MPV,DD and FDP levels were positively correlated with NIHSS score（r=0.871 0,P<0.05;r=0.483 2,P<0.05;r=0.478 1,P<0.05）. A linear correlation was found between MPV level and DD and FDP levels（r=0.426 1,P<0.05;r=0.438 9,P<0.05）. Conclusions MPV,DD and FDP are correlated with CI and its pathological degree,they may be used as independent predictors of CI severity and play roles in prognosis assessment.

Key words: Cerebral infarction, Mean platelet volume, D-dimer, Fibrinogen degradation product, Infarct volume, Lesion severity