Abstract:

Objective To investigate the diagnostic value of maternal plasma D-dimer（DD） and hypertensive disorders of pregnancy（HDP） in the 28-32 gestational weeks. Methods The data of 2 299 pregnant women who delivered in Hangzhou Women's Hospital（Hangzhou Maternity and Child Health Care Hospital） from November 2014 to April 2019 were collected. There were 299 gestational hypertension（GH） patients,158 preeclampsia（PE） patients and 137 severe preeclampsia（SPE） patients. A total of 1 705 healthy pregnant women were enrolled as control group. The performance of DD for HDP was evaluated by receiver operating characteristic（ROC） curve. Results In GH,PE and SPE groups,the levels of DD were 1 730,1 950 and 2 030 μg/L,respectively,which were higher than that in control group（1 520 μg/L,P<0.001）. With progress,the DD levels increased gradually. For the diagnosis of GH,PE and SPE,the areas under curves（AUC） of DD were 0.560（0.525-0.595,P=0.001）,0.614（0.567-0.660,P<0.001） and 0.640（0.589-0.692,P<0.001）,respectively. When the cut-off values of DD were 1 325,1 875 and 1 795 μg/L,the sensitivities were 0.746,0.544 and 0.635,and the specificities were 0.389,0.652 and 0.624,respectively. Conclusions The levels of DD in the late trimester of pregnancy play a predictive role to HDP.

Key words: Late pregnancy, D-dimer, hypertensive disorders of pregnancy, Diagnostic value