Abstract:

Objective To investigate the roles of lymphocyte parameters in the diagnosis of diffuse large B-cell lymphoma（DLBCL）. Methods A total of 60 healthy subjects（healthy control group）,44 patients with DLBCL,24 patients with chronic lymphocytic leukaemia（CLL）,42 patients with other non-Hodgkin lymphomas（NHL） and 40 patients with infectious mononucleosis（IM） were enrolled,and their lymphocyte parameters were determined. The difference between DLBCL and the other groups was evaluated. Receiver operating characteristic（ROC） curve was used to evaluate the diagnostic efficiency of different lymphocyte parameters for DLBCL. Results Compared with healthy control group,DLBCL group had statistical significance in LY-X,LY-Y and LY-WZ,their areas under ROC curves（AUC） were 0.644,0.655 and 0.742,and the optimal cut-off values were 76.9,69.1 and 536,respectively. Compared with CLL group,the differences of LY-X,LY-WX,LY-WY and LY-WZ were statistically significant,the AUC were 0.772,0.608,0.863 and 0.827,and the optimal cut-off values were 79.4,612,1 020 and 533,respectively. Compared with other NHL group,LY-WZ had statistical significance,the AUC was 0.575,and the optimal cut-off value was 588. Compared with IM group,LY-Z,LY-WX,LY-WY and LY-WZ were statistically significant,the AUC were 0.772,0.561,0.777 and 0.887,and the optimal cut-off values were 60.9,612,1 022 and 633,respectively. Conclusions Lymphocyte parameters have a certain value for the diagnosis of DLBCL.

Key words: Diffuse large B-cell lymphoma, Lymphocyte parameter, Diagnostic value