Abstract:

Objective To investigate the roles of serum amyloid A（SAA）,C-reactive protein（CRP）,the absolute value of lymphocyte（LYMPH#）,N-terminal B type natriuretic peptide（NT-proBNP） and D-dimer（DD） in the diagnosis of corona virus disease 2019（COVID-19）. Methods A total of 98 patients with COVID-19 were enrolled,and there were 64 cases of common type,20 cases of severe type and 14 cases of critical type. Totally,40 fever patients excluding severe acute respiratory syndrome coronavirus 2（SARS-CoV-2） infection were enrolled as control group. SAA,CRP,LYMPH#,NT-proBNP and DD levels were determined. The changes of the indexes of COVID-19 critical and severe patients during hospitalization were monitored dynamically. Receiver operating characteristic（ROC） curve was used to evaluate the diagnostic efficiency of each index for COVID-19. Results There were statistical significance of SAA,CRP,LYMPH#,NT-proBNP and DD in critical group,severe group and common type group of COVID-19（P<0.05,P<0.01）. There was no statistical significance between common type group and control group（P>0.05）. Severe patients and critical patients with COVID-19 were combined into a group. ROC curve analysis showed that the areas under curves of SAA,CRP,LYMPH#,NT-proBNP and DD in the diagnosis of severe and critical COVID-19 was 0.930,0.872,0.846,0.731 and 0.815,respectively. The continuous monitoring results showed that SAA,CRP,NT-proBNP and DD of critical group were maintained at high levels,and began to decrease at about the 21 day. LYMPH# continued to maintain at a low level,and began to increase gradually at about the 21 day. The 5 indexes of severe group did not fluctuate significantly. Conclusions SAA,CRP,LYMPH#,NT-proBNP and DD can be used as auxiliary diagnostic indicators of COVID-19. Dynamic monitoring of the 5 indicators has reference value for the judgment and prognosis of COVID-19.

Key words: Amyloid A, C-reactive protein, Absolute value of lymphocyte, N-terminal B-type natriuretic peptide, D-dimer, Corona virus disease 2019