Abstract:

Objective To investigate the predictive value of the combined determination of plasma D-dimer and fibrinogen degradation product（FDP） in pre-eclampsia in the third trimester of pregnancy. Methods A total of 126 women with singleton pregnancy and pre-eclampsia,including 40 patients with severe pre-eclampsia and 86 patients with mild pre-eclampsia,were enrolled. A total of 136 healthy pregnant women were enrolled as control group. The plasma D-dimer and FDP were determined. Receiver operating characteristic（ROC） curve analysis was used to evaluate the predictive value of the combined determination of plasma D-dimer and FDP levels in pre-eclampsia. Results Plasma D-dimer and FDP levels in the pre-eclampsia group were higher than those in control group（P<0.05）. Between severe and mild pre-eclampsia groups,there was no statistical significance in plasma D-dimer and FDP in late trimester of pregnancy（P>0.05）. ROC curve analysis showed that the areas under curves of D-dimer and FDP in the diagnosis of pre-eclampsia were 0.855 and 0.869,and the optimal cut-off values were 3.64 mg/L FEU and 10.65 μg/mL. The sensitivities were 83.5% and 86.7%,and the specificities were 65.0% and 60.0%. Conclusions Plasma D-dimer and FDP levels in the third trimester are closely related to the occurrence of pre-eclampsia,and have predictive values for pre-eclampsia.

Key words: D-dimer, Fibrinogen degradation product, Pre-eclampsia