Abstract:

Objective To investigate the diagnostic value of D-dimer（DD） level in different types of pancreatitis. MethodsTotally,60 patients with acute pancreatitis were enrolled,and there were 40 cases of mild pancreatitis（mild group） and 20 cases of severe pancreatitis（severe group）. A total of 60 healthy subjects were enrolled as control group. The levels of DD,prothrombin time（PT）,activated partial thromboplastin time（APTT） and thrombin time（TT） were determined. Results The DD,PT,APTT and TT in severe group at admission were higher than those in mild group and control group（P<0.05）. The DD,PT,APTT and TT in mild group at admission were higher than those in control group（P<0.05）. The levels of DD,PT,APTT and TT in mild and severe groups at 3 d after admission were higher than those at admission（P<0.05）,and those at 7 d after admission in mild group were decreased（P<0.05）,while those in severe group continued to increase（P<0.05）. In severe group,DD,PT,APTT and TT at admission and 3 d,7 d after admission were higher than those in mild group（P<0.05）. The areas under receiver operating characteristic（ROC） curves of DD,PT,APTT and TT at admission in judging the severity of acute pancreatitis were 0.866,0.801,0.776 and 0.835,respectively（P<0.05）. Conclusions DD,PT,APTT and TT determinations play roles in the early diagnosis of acute pancreatitis and the assessment of disease severity.

Key words: D-dimer, Prothrombin time, Activated partial thromboplastin time, Thrombin time, Acute pancreatitis, Severity