Establishment on the reference intervals of serum lipoprotein-associated phospholipase A2 in apparently healthy adults

doi:10.3969/j.issn.1673-8640.2017.06.011

Abstract

Abstract:

Objective To establish the reference intervals of serum lipoprotein-associated phospholipase A₂ （Lp-PLA₂）in apparently healthy adults. Methods The activities of serum Lp-PLA₂ in 800 apparently healthy adults （400 males and 400 females） were determined,and the 95% reference intervals [the 2.5th percentile （P_2.5）-the 97.5th percentile （P_97.5）,90% confidence interval] were determined,according to the Clinical and Laboratory Standards Institute （CLSI）C28-A3. Results Serum Lp-PLA₂ activities showed a normal distribution in apparently healthy adults. The reference intervals of serum Lp-PLA₂ activities were（479±126） U/L in males and （433±118） U/L in females with statistical significance（t=5.311,P<0.01）. Serum Lp-PLA₂ activities were stable in males,while those in females increased with age,and there was statistical significance for age （F=2.017,P<0.05）. There was no statistical significance for serum Lp-PLA₂ activities in females between <50 years old and ≥50 years old （P>0.05）,and thus females could be classified into 18-49 years old group and 50-89 years old group. Therefore,the reference intervals of serum Lp-PLA₂activities in apparently healthy adults were 219-694 U/L for males,204-651 U/L for 18-49 years old females and 217-686 U/L for 50-89 years old females. Conclusions The reference intervals of serum Lp-PLA₂ activities in apparently healthy adults have been established initially,which provide a reference for the clinical application of serum Lp-PLA₂ as an indicator for the assessment of cardiovascular risk.

Key words: Lipoprotein-associated phospholipase A2, Apparently healthy adults, Reference interval

CLC Number:

Q556

FENG Ruijie, HU Xiaochen, ZHAO Lifang, ZHANG Haichen, SONG Yunxiao. Establishment on the reference intervals of serum lipoprotein-associated phospholipase A₂ in apparently healthy adults[J]. Laboratory Medicine, 2017, 32(6): 495-499.

Figures/Tables 5

References 20

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性别	例数	年龄（岁）	Lp-PLA₂（U/L）
男性	400	49.0（18~85）	479±126
女性	400	48.0（18~89）	433±118^*
合计	800	48.5（18~89）	456±124

性别	例数	年龄（岁）	Lp-PLA₂（U/L）
男性	400	49.0（18~85）	479±126
女性	400	48.0（18~89）	433±118^*
合计	800	48.5（18~89）	456±124

组别	例数	Lp-PLA₂（U/L）
组别	例数	x±s	中位数	P_2.5	P_97.5
男性
18~29岁	69	479±125	457	295	695
30~39岁	67	476±127	479	213	680
40~49岁	66	481±125	503	218	704
50~59岁	66	478±127	491	227	709
60~69岁	66	479±127	481	201	705
≥70岁	66	482±129	518	209	688
女性
18~29岁	80	416±111^*#△	413	214	671
30~39岁	70	417±110^*#△	398	206	684
40~49岁	64	415±111^*#△	413	152	639
50~59岁	65	451±124	433	184	685
60~69岁	61	455±124	459	205	691
≥70岁	60	454±125	436	269	692

组别	例数	Lp-PLA₂（U/L）
组别	例数	x±s	中位数	P_2.5	P_97.5
男性
18~29岁	69	479±125	457	295	695
30~39岁	67	476±127	479	213	680
40~49岁	66	481±125	503	218	704
50~59岁	66	478±127	491	227	709
60~69岁	66	479±127	481	201	705
≥70岁	66	482±129	518	209	688
女性
18~29岁	80	416±111^*#△	413	214	671
30~39岁	70	417±110^*#△	398	206	684
40~49岁	64	415±111^*#△	413	152	639
50~59岁	65	451±124	433	184	685
60~69岁	61	455±124	459	205	691
≥70岁	60	454±125	436	269	692

组别	例数	中位数	百分位数
组别	例数	中位数	2.5	25	50	75	97.5
女性
18~49岁	186	410	204	340	410	487	651
50~89岁	214	436	217	370	436	537	686
男性	400	485	219	386	485	576	694

Establishment on the reference intervals of serum lipoprotein-associated phospholipase A₂ in apparently healthy adults

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参考区间来源	性别	样本数	年龄（岁）	参考区间
试剂说明书	女性			≤535 U/L
	男性			≤670 U/L
本研究	女性	400	18~49	204~651 U/L
			50~89	217~686 U/L
	男性	400	18~85	219~694 U/L
FENG等^[10]研究	女性	371	18~49	194~640 U/L
			50~88	208~698 U/L
	男性	392	18~87	230~728 U/L
KOSAKA等^[14]研究	女性	1 965	18~94	350.5 U/L
	男性	1 141	18~93	367.8 U/L
LEE等^[13]研究		52	60~72	（124±61）nmol/（min · mL）

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