Investigation of lipoprotein-associated phospholipase A2 levels among apparently healthy population in Wuhan

doi:10.3969/j.issn.1673-8640.2020.09.008

Abstract

Abstract:

Objective To investigate the distribution of lipoprotein-associated phospholipase A2（Lp-PLA2） among apparently healthy population in Wuhan. Methods Totally,1 503 apparently healthy subjects were enrolled. The levels of serum amyloid A（SAA）,Lp-PLA2 and homocysteine（Hcy） were determined. The data fo sex and age and the determination result data of total bilirubin （TB）,direct bilirubin （DBil）,alanine aminotransferase （ALT）,aspartate aminotransferase （AST）,alkaline phosphatase （ALP）,gamma-glutamyltransferase （GGT）,blood urea nitrogen （BUN）,creatinine （Cr）,uric acid （UA）,cystatin C （Cys C）,glucose （Glu）,total cholesterol （TC）,triglyceride （TG）,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol （LDL-C）,apolipoprotein A （apo A）,apolipoprotein B （apo B） and lipoprotein（a）[Lp（a）] were collected. The correlation between Lp-PLA2 and the other indicators was analyzed by Spearman correlation. Results Lp-PLA2 ≥200 ng/mL was used as increasing（positive）. The Lp-PLA2 level and positive rate of males were higher than those of females（P<0.001）. The positive rate of Lp-PLA2 in ≥61-year-old group was higher than those in 41-60-year-old group and ≤40-year-old group,and serum Lp-PLA2 level was the highest in 41-60-year-old group. In increased Lp-PLA2 group,the age,SAA,ALT,AST,ALP,GGT,BUN,UA,Cr,Cys C,Glu,TG,apo B and Hcy were higher than those in normal Lp-PLA2 group（P<0.05）. TB,DBil,HDL-C and apo A were lower than those in normal Lp-PLA2 group（P<0.05）. There was no statistical significance in TC,LDL-C and Lp（a） between the 2 groups（P>0.05）. The levels of Lp-PLA2,SAA,GGT and Glu in Lp-PLA2 highly increased（>400 ng/mL） group were higher than those in Lp-PLA2 moderately increased（301-400 ng/mL） and slightly increased（200-300 ng/mL） groups（P<0.05）. There was no statistical significance for the other indicators among the 3 groups（P>0.05）. Spearman correlation analysis showed that Lp-PLA2 was positively correlated with SAA and GGT（r=0.422 and 0.162,P<0.001 and P=0.001,respectively）,and it had no correlation with the other indicators（P>0.05）. Conclusions Lp-PLA2 is high among apparently healthy population in Wuhan. Lp-PLA2 screening is necessary in apparently healthy population.

Key words: Lipoprotein-associated phospholipase A2, Cardio-cerebrovascular disease, Physical examination

CLC Number:

R446.1

LIANG Tao, LIU Feng, ZHANG Detai, WANG Lin, HU Lihua. Investigation of lipoprotein-associated phospholipase A2 levels among apparently healthy population in Wuhan[J]. Laboratory Medicine, 2020, 35(9): 889-894.

Figures/Tables 6

References 6

[1]	ZHOU F,LIU Y,SHI H,et al.Relation between lipoprotein-associated phospholipase A2 mass and incident ischemic stroke severity[J]. Neurol Sci,2018,39(9):1591-1596.
[2]	YANG L,WANG H,ZHANG Y,et al.The prognostic value of lipoprotein-associated phospholipase A2 in the long-term care of patients with acute coronary syndrome undergoing percutaneous coronary intervention[J]. Clin Appl Thromb Hemost,2018,24(5):822-827.
[3]	中国老年学学会心脑血管病专业委员会,中国医师协会检验医师分会心脑血管病专家委员会. 脂蛋白相关磷脂酶A2临床应用专家建议[J]. 中华心血管病杂志,2015,43(10):843-847.
[4]	FATEMI S,GOTTSÄTER A,ZARROUK M,et al. Lp-PLA2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease[J]. Sci Rep,2019,9(1):5609.
[5]	廖琳,胡敏,陈若虹,等. 长沙地区体检健康成人血清脂蛋白相关磷脂酶A2活性参考区间的建立[J]. 临床检验杂志,2018,36(6):422-425.
[6]	丰睿捷,胡晓晨,赵莉芳,等. 表观健康人群血清脂蛋白相关磷脂酶A2参考区间的建立[J]. 检验医学,2017,32(6):495-499.

组别	例数	年龄/岁	Lp-PLA2/（ng/mL）	Lp-PLA2阳性例数/%
男性组	1 010	48（42~55）	241（130~365）	315（31.19）
女性组	493	49（42~55）	101（100~172）	98（19.88）
统计值		1.674	6.816	21.265
P值		0.094	<0.001	<0.001

组别	例数	年龄/岁	Lp-PLA2/（ng/mL）	Lp-PLA2阳性例数/%
男性组	1 010	48（42~55）	241（130~365）	315（31.19）
女性组	493	49（42~55）	101（100~172）	98（19.88）
统计值		1.674	6.816	21.265
P值		0.094	<0.001	<0.001

组别	例数	Lp-PLA2/ （ng/mL）	阳性例数/%
≤40岁组	318	125（100~289）	81（25.47）
41~60岁组	1 048	295（235~390）^*	287（27.39）
≥61岁组	137	130（100~251）^#	45（32.85）^*#

组别	例数	Lp-PLA2/ （ng/mL）	阳性例数/%
≤40岁组	318	125（100~289）	81（25.47）
41~60岁组	1 048	295（235~390）^*	287（27.39）
≥61岁组	137	130（100~251）^#	45（32.85）^*#

组别	例数	Lp-PLA2/ （ng/mL）	阳性例数/%
≤40岁组	222	282（158~391）	67（30.18）
41~60岁组	695	301（234~407）	215（30.94）
≥61岁组	93	143（100~283）^*#	33（35.48）^*#