Abstract:

Objective To investigate the relationships of plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) with atherosclerotic cardio-cerebrovascular disease. Methods A total of 198 patients with atherosclerotic cardio-cerebrovascular disease were classified into the group with traditional risk factors and the group without traditional risk factors. A total of 58 healthy subjects were enrolled as healthy control group. The plasma concentration of Lp-PLA2 was detected by double-antibody sandwich enzyme-linked immunosorbent assay(ELISA), and Hcy level was detected by enzymatic cycling method. Results Compared with healthy control group, Lp-PLA2 and Hcy levels increased significantly in both groups with and without traditional risk factors (q=44.236, P=0.000; q=11.403, P=0.000; q=50.025, P=0.000; q=15.777, P=0.000). No statistical significance was found between groups with and without traditional risk factors for Lp-PLA2 and Hcy levels (q=2.299, P=0.083; q=2.586, P=0.069). Lp-PLA2 and Hcy levels in groups with and without traditional risk factors had no correlation (r=0.069, P=0.375;r=0.053, P=0.566). Balanced other risk factors, Lp-PLA2 and Hcy levels were independently correlated with coronary heart disease (OR=1.917, P=0.005; OR=1.883, P=0.013). Higher positive rate can be got by Lp-PLA2 and Hcy combined detection than the individual detections in both groups with and without traditional risk factors (χ²=8.124, P=0.004; χ²=3.933, P=0.045). Conclusions Plasma Lp-PLA2 and Hcy levels can be used in risk assessment of atherosclerotic disease,and the combined detection has some predictive significance for atherosclerotic cardio-cerebrovascular disease.

Key words: Lipoprotein-associated phospholipase A2, Homocysteine, Atherosclerotic cardio-cerebrovascular disease, Correlation, Combined detection