Abstract:

Objective To study high prolactin（PRL） caused by risperidone-related factors,and to guide clinicians using drugs rationally. Methods Totally,90 patients with schizophrenia were enrolled after treatment of risperidone for 6 weeks. The general data,including age,sex,body mass index（BMI）,positive and negative syndrome scale（PANSS） score,plasma concentration of risperidone,fasting blood glucose,total cholesterol（TC）,triglyceride（TG） and the level of PRL,were collected. According to plasma concentrations of PRL,the research subjects were classified into high PRL group（PRL≥30 ng/mL） and normal PRL group（PRL<30 ng/mL）. Results The proportion of females in high PRL group was higher than that in normal PRL group（P<0.001）,and PANSS score and fasting blood glucose were lower than those in normal PRL group（P<0.001）. Age,BMI,TC,TG and plasma concentration of risperidone had no statistical significance between the 2 groups（P>0.05）. Logistic regression analysis showed that high PRL was associated with sex（female）,PANSS score and fasting blood glucose [odds ratios（OR） were 15.843,0.466 and 0.053,95% confidence intervals（CI） were 5.329-47.105,0.259-0.838 and 0.014-0.202,P<0.05]. Age,BMI,TC,TG and plasma concentration of risperidone were not risk factors for high PRL（OR=1.016,1.623,0.449,0.650 and 0.399,P>0.05）. PRL in female patients was higher than that in male patients（P<0.001）. Conclusions Female patients taking risperidone are easier to be high PRL,and patients taking risperidone with low PANSS score and low fasting blood glucose are tended to be high PRL. Clinicians should use individualized medication.

Key words: Prolactin, Risperidone, Schizophrenia, Correlation