Abstract:

Objective To study the role of therapeutic drug monitoring（TDM） by the retrospective analysis of 5 common drugs' TDM results in patients with mental diseases. Methodse The TDM results of 2 mood stabilizers（valproic acid,carbamazepine） and 3 antipsychotics（clozapine,olanzapine,palisperidone） in 721 patients with mental diseases were analyzed retrospectively,and the control rates of the 5 drugs before and after TDM were compared. Results The control rates of valproic acid and carbamazepine before TDM were 31.15% and 33.33%,while those after TDM increased to 81.53% and 81.82%,respectively. The control rates of clozapine,olanzapine and palisperidone before TDM were 24.35%,67.32% and 68.75%,while those after TDM increased to 62.61%,83.01% and 83.13%,respectively. Compared with before TDM,the control rates of the 5 drugs after TDM were increased（P<0.05）. After TDM,the increase rate of valproic acid for the control rate（50.38%） was higher than those of clozapine,olanzapine and palisperidone（38.26%,15.69% and 14.38%,respectively）（P<0.05）,while the increase rate of carbamazepine for the control rate（48.49%） was higher than those of olanzapine and palisperidone（15.69% and 14.38%,respectively）（P<0.05）. Conclusions TDM can effectively guide clinical drug use,realize individual drug use and achieve optimal therapeutic effect.

Key words: Therapeutic drug monitoring, Schizophrenia, Bipolar disorder