A total of 6 112 subjects in Shanghai undergoing healthy physical examination, including serum thyroid hormone and thyroid autoantibody determinations, were enrolled. Their fasting venous blood samples were collected at early morning. Serum triiodothyronine(T3),thyroxin(T4),free triiodothyonine(FT3),free thyroxin(FT4),thyroid stimulating hormone(TSH),anti-thyroglobulin antibody(TGAb) and thyroid peroxidase antibody(TPOAb) were detected by SIEMENS ADVIA CENTAUR XP automatic chemiluminescence analyzer. The results were analyzed statistically.

Among the 6 112 subjects, the detection rates of hyperthyroidism, hypothyroidism, subclinical hyperthyroidism and subclinical hypothyroidism were 0.47, 0.34, 0.62 and 2.55, respectively. Female incidence rates of hyperthyroidism, hypothyroidism, subclinical hyerthyroidism and subclinical hypothyroidism were higher than those in males(P=0.001). Female abnormal rates of serum thyroid hormone and thyroid autoantibodies were significantly higher than those in males(P=0.001). Serum thyroid hormone in 10.37% of the subjects was normal, however, with the increasing levels of thyroid autoantibodies. With the increasing of age, the incidence rate of thyroid dysfunction and the abnormal rates of serum thyroid hormone and thyroid autoantibodies showed a trend of increase.

Hypothyroidism and subclinical hypothyroidism are major thyroid dysfunctions in Shanghai, with higher female incidence and abnormal rates than male's, and there is a relationship with age. The determinations of thyroid hormone and thyroid autoantibodies in healthy physical examination are very necessary and valuable.